Relationship of the apolipoprotein E polymorphism with carotid artery atherosclerosis

M. De Andrade, I. Thandi, S. Brown, A. Gotto, W. Patsch, E. Boerwinkle

Research output: Contribution to journalArticle

90 Scopus citations

Abstract

From the cohort taking part in the Atherosclerosis Risk in Communities (ARIC) study, a multicenter investigation of atherosclerosis and its sequelae in women and men ages 45-64 years, a sample of 145 subjects with significant carotid artery atherosclerosis but without clinically recognized coronary heart disease was identified along with 224 group-matched control subjects. The aim of this paper is to measure the association of the apolipoprotein (apo) E polymorphism with the prevalence of significant carotid artery atherosclerotic disease (CAAD) after considering the contribution of established risk factor variables. The first model used a stepwise selection procedure to define a group of significant physical and lifestyle characteristics and a group of significant plasma lipid, lipoprotein, and apolipoprotein variables that were predictive of CAAD status in this sample. Those variables selected included age (years), body mass index (BMI; kg/m2), consumption of cigarettes (CigYears; number of cigarettes/d x the number of smoking years), hypertension status, high-density lipoprotein (HDL)- cholesterol (mg/dl), total cholesterol (mg/dl), and Lp[a] (μg/ml). The second model was built by forcing into the equation an a priori set of demographic, anthropometric, and lipoprotein variables, which were age, BMI, CigYears, hypertensive status, LDL-cholesterol, and HDL-cholesterol. In both models, the apo E genotype ε2/3 was related to CAAD status. For both models, the estimated odds ratio of being a CAAD case associated with the apo E genotype ε2/3 was >2:1. The mechanism of the observed association between the ε2/3 genotype and carotid atherosclerosis is unknown, but it is likely due to the known effects of the E2 isoform in causing delayed clearance of triglyceride-rich lipoproteins.

Original languageEnglish (US)
Pages (from-to)1379-1390
Number of pages12
JournalAmerican journal of human genetics
Volume56
Issue number6
StatePublished - Jan 1 1995

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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    De Andrade, M., Thandi, I., Brown, S., Gotto, A., Patsch, W., & Boerwinkle, E. (1995). Relationship of the apolipoprotein E polymorphism with carotid artery atherosclerosis. American journal of human genetics, 56(6), 1379-1390.