TY - JOUR
T1 - Relationship of fuchs endothelial corneal dystrophy severity to central corneal thickness
AU - Kopplin, Laura J.
AU - Przepyszny, Katie
AU - Schmotzer, Brian
AU - Rudo, Karen
AU - Babineau, Denise C.
AU - Patel, Sanjay V.
AU - Verdier, David D.
AU - Jurkunas, Ula
AU - Iyengar, Sudha K.
AU - Lass, Jonathan H.
PY - 2012/4
Y1 - 2012/4
N2 - Objective: To define the relationship between Fuchs endothelial corneal dystrophy (FECD) severity and central corneal thickness (CCT). Methods: We examined 1610 eyes from a subset of index cases, family members, and unrelated control subjects with normal corneas from the FECD Genetics Multi- Center Study. To estimate the association between FECD severity grade (7-point severity scale based on guttae confluence) andCCTmeasured by ultrasonographic pachymetry, a multivariable model was used that adjusted for eye, age, race, sex, history of glaucoma or ocular hypertension, diabetes mellitus, contact lens wear, intraocular pressure, and familial relationship to the index case. An interaction between FECD severity grade and edema (stromal or epithelial) on slitlamp examination findings was used to investigate whether the effect of FECD severity grade onCCTdiffered between those with and without edema. Results: Average CCT was thicker in index cases for all FECD grades compared with unaffected controls (P ≤ .003) and in affected family members with an FECD grade of 4 or greater compared with unaffected family members (P ≤ .04). Similar results were observed for subjects without edema. Average CCT of index cases was greater than that of affected family members with grades 4, 5, and 6 FECD (P ≤ .02). Intraocular pressure was also associated with CCT (P=.01). Conclusions: An increase in CCT occurs with increasing severity of FECD, including at lower FECD grades in which clinically observable edema is not present. Monitoring CCT changes serially could be a more sensitive measure of disease progression with surgical therapeutic implications.
AB - Objective: To define the relationship between Fuchs endothelial corneal dystrophy (FECD) severity and central corneal thickness (CCT). Methods: We examined 1610 eyes from a subset of index cases, family members, and unrelated control subjects with normal corneas from the FECD Genetics Multi- Center Study. To estimate the association between FECD severity grade (7-point severity scale based on guttae confluence) andCCTmeasured by ultrasonographic pachymetry, a multivariable model was used that adjusted for eye, age, race, sex, history of glaucoma or ocular hypertension, diabetes mellitus, contact lens wear, intraocular pressure, and familial relationship to the index case. An interaction between FECD severity grade and edema (stromal or epithelial) on slitlamp examination findings was used to investigate whether the effect of FECD severity grade onCCTdiffered between those with and without edema. Results: Average CCT was thicker in index cases for all FECD grades compared with unaffected controls (P ≤ .003) and in affected family members with an FECD grade of 4 or greater compared with unaffected family members (P ≤ .04). Similar results were observed for subjects without edema. Average CCT of index cases was greater than that of affected family members with grades 4, 5, and 6 FECD (P ≤ .02). Intraocular pressure was also associated with CCT (P=.01). Conclusions: An increase in CCT occurs with increasing severity of FECD, including at lower FECD grades in which clinically observable edema is not present. Monitoring CCT changes serially could be a more sensitive measure of disease progression with surgical therapeutic implications.
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U2 - 10.1001/archopthalmol.2011.1626
DO - 10.1001/archopthalmol.2011.1626
M3 - Article
C2 - 22491913
AN - SCOPUS:84860009374
SN - 0003-9950
VL - 130
SP - 433
EP - 439
JO - Archives of ophthalmology
JF - Archives of ophthalmology
IS - 4
ER -