Relationship of blood pressure measures with coronary artery calcification

Lama S. Jamjoum, Lawrence F. Bielak, Stephen T Turner, Patrick F. Sheedy, Eric Boerwinkle, Trivellore E. Raghunathan, Patricia A. Peyser

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Increased blood pressure level is a major risk factor for coronary artery disease. Previous studies of relationships of blood pressure level and hypertension status with coronary artery calcification (CAC), a measure of subclinical atherosclerosis, were restricted to participants who were physician- or self-referred, high risk, selected on hypertension status, or young adults. Material/Methods: 803 asymptomatic individuals at least age 40 years were studied from a community. Blood pressure level was measured and blood pressure diagnostic category (i.e. hypertension vs. normotension) was determined by considering reported history of physician-diagnosed hypertension, use of antihypertensive medication, and measured blood pressure levels. CAC was measured non-invasively with electron beam computed tomography. Tobit regression models allowed simultaneous modeling of presence and quantity of CAC. Results: In men, age, having ever smoked, having hypertension, LDL-C level, and body mass index were significantly and positively associated with presence and quantity of CAC. In women, age, systolic blood pressure level, use of lipid lowering medications, and waist-to-hip ratio were significantly and positively associated with presence and quantity of CAC. Relationships of measures of blood pressure with CAC were modified by age, but no other risk factors, in both sexes. Conclusions: Our results indicated that measures of blood pressure make a relatively large contribution to predictions of CAC at younger ages. CAC quantification, especially among younger individuals, may allow for early assessment of the presence and extent of target organ disease.

Original languageEnglish (US)
JournalMedical Science Monitor
Volume8
Issue number12
StatePublished - Dec 1 2002

Fingerprint

Coronary Vessels
Blood Pressure
Hypertension
Physicians
X Ray Computed Tomography
Waist-Hip Ratio
Antihypertensive Agents
Coronary Artery Disease
Young Adult
Atherosclerosis
Body Mass Index
Lipids

Keywords

  • Blood pressure
  • Calcinosis
  • Coronary vessels
  • Hypertension
  • Risk factors
  • Tomography
  • X-ray computed

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Jamjoum, L. S., Bielak, L. F., Turner, S. T., Sheedy, P. F., Boerwinkle, E., Raghunathan, T. E., & Peyser, P. A. (2002). Relationship of blood pressure measures with coronary artery calcification. Medical Science Monitor, 8(12).

Relationship of blood pressure measures with coronary artery calcification. / Jamjoum, Lama S.; Bielak, Lawrence F.; Turner, Stephen T; Sheedy, Patrick F.; Boerwinkle, Eric; Raghunathan, Trivellore E.; Peyser, Patricia A.

In: Medical Science Monitor, Vol. 8, No. 12, 01.12.2002.

Research output: Contribution to journalArticle

Jamjoum, LS, Bielak, LF, Turner, ST, Sheedy, PF, Boerwinkle, E, Raghunathan, TE & Peyser, PA 2002, 'Relationship of blood pressure measures with coronary artery calcification', Medical Science Monitor, vol. 8, no. 12.
Jamjoum LS, Bielak LF, Turner ST, Sheedy PF, Boerwinkle E, Raghunathan TE et al. Relationship of blood pressure measures with coronary artery calcification. Medical Science Monitor. 2002 Dec 1;8(12).
Jamjoum, Lama S. ; Bielak, Lawrence F. ; Turner, Stephen T ; Sheedy, Patrick F. ; Boerwinkle, Eric ; Raghunathan, Trivellore E. ; Peyser, Patricia A. / Relationship of blood pressure measures with coronary artery calcification. In: Medical Science Monitor. 2002 ; Vol. 8, No. 12.
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