Relationship between Triglyceride Tolerance, Body Mass Index, and Fat Depots in Hospitalized Patients Receiving Parenteral Nutrition

Erin N. Frazee, Erin M. Nystrom, M. Molly McMahon, Eric E. Williamson, John M. Miles

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Background: Hypertriglyceridemia has been associated with adverse outcomes in patients receiving intravenous fat emulsions (IVFEs), but little is known about its prevalence and causes. Materials and Methods: The study investigated whether a relationship exists between body mass index (BMI) and triglyceride tolerance in parenterally fed patients. We conducted a retrospective analysis of 287 adults receiving parenteral nutrition to determine whether patients with very low BMI (VLBMI, 2) tolerate IVFEs better than do patients with low BMI (LBMI, 16-18.4 kg/m2), normal-weight patients (NBMI, 18.5-24.9 kg/m2), and overweight/obese patients (HBMI, ‰25 kg/m2). Results: The median triglyceride concentration during IVFE was significantly lower in VLBMI patients at 107 mg/dL compared with 124 mg/dL in non-VLBMI patients (P =.016), despite higher lipid infusion rates in the VLBMI group. There was a significant association between triglycerides and BMI in the aggregate cohort (R = 0.2375, P

Original languageEnglish (US)
Pages (from-to)922-928
Number of pages7
JournalJournal of Parenteral and Enteral Nutrition
Volume39
Issue number8
DOIs
StatePublished - Nov 1 2015

Keywords

  • adult
  • life cycle
  • lipids
  • nutrition
  • obesity
  • parenteral nutrition
  • research and diseases

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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