TY - JOUR
T1 - Relationship between shear stiffness measured by mr elastography and perfusion metrics measured by perfusion ct of meningiomas
AU - Takamura, T.
AU - Motosugi, U.
AU - Ogiwara, M.
AU - Sasaki, Y.
AU - Glaser, K. J.
AU - Ehman, R. L.
AU - Kinouchi, H.
AU - Onishi, H.
N1 - Funding Information:
Received June 20, 2020; accepted after revision January 10, 2021. From the Department of Radiology (T.T.), Shizuoka General Hospital, Shizuoka, Japan; Department of Radiology (T.T.), Juntendo University, Tokyo, Japan; Department of Radiology (U.M.), Kofu-Kyoritsu Hospital, Yamanashi, Japan; Departments of Neurosurgery (M.O., H.K.) and Radiology (Y.S., H.O.), University of Yamanashi, Yamanashi, Japan; and Department of Radiology (K.J.G., R.L.E.), Mayo Clinic College of Medicine, Rochester, Minnesota. This work was supported, in part, by the National Institutes of Health, R37 EB001981. Please address correspondence to Tomohiro Takamura, MD, PhD, Department of Radiology, Shizuoka General Hospital, 4-27-1 Kita Ando Aoi-ku, Shizuoka City 420-8527, Japan; e-mail: t-takamura@i.shizuoka-pho.jp
Publisher Copyright:
© 2021 American Society of Neuroradiology. All rights reserved.
PY - 2021/7/1
Y1 - 2021/7/1
N2 - BACKGROUND AND PURPOSE: When managing meningiomas, intraoperative tumor consistency and histologic subtype are indispensable factors influencing operative strategy. The purposes of this study were the following: 1) to investigate the correlation between stiffness assessed with MR elastography and perfusion metrics from perfusion CT, 2) to evaluate whether MR elastography and perfusion CT could predict intraoperative tumor consistency, and 3) to explore the predictive value of stiffness and perfusion metrics in distinguishing among histologic subtypes of meningioma. MATERIALS AND METHODS: Mean tumor stiffness and relative perfusion metrics (blood flow, blood volume, and MTT) were calculated (relative to normal brain tissue) for 14 patients with meningiomas who underwent MR elastography and perfusion CT before surgery (cohort 1). Intraoperative tumor consistency was graded by a neurosurgeon in 18 patients (cohort 2, comprising the 14 patients from cohort 1 plus 4 additional patients). The correlation between tumor stiffness and perfusion metrics was evaluated in cohort 1, as was the ability of perfusion metrics to predict intraoperative tumor consistency and discriminate histologic subtypes. Cohort 2 was analyzed for the ability of stiffness to determine intraoperative tumor consistency and histologic subtypes. RESULTS: The relative MTT was inversely correlated with stiffness (P=.006). Tumor stiffness was positively correlated with intraoperative tumor consistency (P=.01), while perfusion metrics were not. Relative MTT significantly discriminated transitional meningioma from meningothelial meningioma (P=.04), while stiffness did not significantly differentiate any histologic subtypes. CONCLUSIONS: In meningioma, tumor stiffness may be useful to predict intraoperative tumor consistency, while relative MTT may potentially correlate with tumor stiffness and differentiate transitional meningioma from meningothelial meningioma.
AB - BACKGROUND AND PURPOSE: When managing meningiomas, intraoperative tumor consistency and histologic subtype are indispensable factors influencing operative strategy. The purposes of this study were the following: 1) to investigate the correlation between stiffness assessed with MR elastography and perfusion metrics from perfusion CT, 2) to evaluate whether MR elastography and perfusion CT could predict intraoperative tumor consistency, and 3) to explore the predictive value of stiffness and perfusion metrics in distinguishing among histologic subtypes of meningioma. MATERIALS AND METHODS: Mean tumor stiffness and relative perfusion metrics (blood flow, blood volume, and MTT) were calculated (relative to normal brain tissue) for 14 patients with meningiomas who underwent MR elastography and perfusion CT before surgery (cohort 1). Intraoperative tumor consistency was graded by a neurosurgeon in 18 patients (cohort 2, comprising the 14 patients from cohort 1 plus 4 additional patients). The correlation between tumor stiffness and perfusion metrics was evaluated in cohort 1, as was the ability of perfusion metrics to predict intraoperative tumor consistency and discriminate histologic subtypes. Cohort 2 was analyzed for the ability of stiffness to determine intraoperative tumor consistency and histologic subtypes. RESULTS: The relative MTT was inversely correlated with stiffness (P=.006). Tumor stiffness was positively correlated with intraoperative tumor consistency (P=.01), while perfusion metrics were not. Relative MTT significantly discriminated transitional meningioma from meningothelial meningioma (P=.04), while stiffness did not significantly differentiate any histologic subtypes. CONCLUSIONS: In meningioma, tumor stiffness may be useful to predict intraoperative tumor consistency, while relative MTT may potentially correlate with tumor stiffness and differentiate transitional meningioma from meningothelial meningioma.
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U2 - 10.3174/ajnr.A7117
DO - 10.3174/ajnr.A7117
M3 - Article
C2 - 33985944
AN - SCOPUS:85110694413
VL - 42
SP - 1216
EP - 1222
JO - American Journal of Neuroradiology
JF - American Journal of Neuroradiology
SN - 0195-6108
IS - 7
ER -