Abstract
Cyclic amegakaryocytic thrombocytopenic purpura is a rare syndrome characterized by periodic failure of megakaryocytopoiesis. In this report we describe a patient with cyclic amegakaryocytic thrombocytopenic purpura associated with a megakaryocyte specific serum IgG antibody, who responded to cyclosporin A therapy. Serial serum thrombopoietin assays during an episode of platelet cycling demonstrated a reciprocal relationship between serum thrombopoietin level and megakaryocyte mass, suggesting that megakaryocytes have an important role in the regulation of thrombopoietin metabolism.
Original language | English (US) |
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Pages (from-to) | 452-458 |
Number of pages | 7 |
Journal | British journal of haematology |
Volume | 105 |
Issue number | 2 |
DOIs | |
State | Published - 1999 |
Keywords
- Cyclic amegakaryocytosis
- Cyclosporin A
- Immune thrombocytopenia
- Thrombopoietin
ASJC Scopus subject areas
- Hematology