Relationship between megakaryocyte mass and serum thrombopoietin levels as revealed by a case of cyclic amegakaryocytic thrombocytopenic purpura

Clive S. Zent, Janina Ratajczak, Mariusz Z. Ratajczak, John Anastasi, Philip C. Hoffman, Alan M. Gewirtz

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Cyclic amegakaryocytic thrombocytopenic purpura is a rare syndrome characterized by periodic failure of megakaryocytopoiesis. In this report we describe a patient with cyclic amegakaryocytic thrombocytopenic purpura associated with a megakaryocyte specific serum IgG antibody, who responded to cyclosporin A therapy. Serial serum thrombopoietin assays during an episode of platelet cycling demonstrated a reciprocal relationship between serum thrombopoietin level and megakaryocyte mass, suggesting that megakaryocytes have an important role in the regulation of thrombopoietin metabolism.

Original languageEnglish (US)
Pages (from-to)452-458
Number of pages7
JournalBritish journal of haematology
Volume105
Issue number2
DOIs
StatePublished - 1999

Keywords

  • Cyclic amegakaryocytosis
  • Cyclosporin A
  • Immune thrombocytopenia
  • Thrombopoietin

ASJC Scopus subject areas

  • Hematology

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