Relationship between megakaryocyte mass and serum thrombopoietin levels as revealed by a case of cyclic amegakaryocytic thrombocytopenic purpura

Clive S. Zent, Janina Ratajczak, Mariusz Z. Ratajczak, John Anastasi, Philip C. Hoffman, Alan M. Gewirtz

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Cyclic amegakaryocytic thrombocytopenic purpura is a rare syndrome characterized by periodic failure of megakaryocytopoiesis. In this report we describe a patient with cyclic amegakaryocytic thrombocytopenic purpura associated with a megakaryocyte specific serum IgG antibody, who responded to cyclosporin A therapy. Serial serum thrombopoietin assays during an episode of platelet cycling demonstrated a reciprocal relationship between serum thrombopoietin level and megakaryocyte mass, suggesting that megakaryocytes have an important role in the regulation of thrombopoietin metabolism.

Original languageEnglish (US)
Pages (from-to)452-458
Number of pages7
JournalBritish Journal of Haematology
Volume105
Issue number2
StatePublished - 1999
Externally publishedYes

Fingerprint

Thrombocytopenic Purpura
Thrombopoietin
Megakaryocytes
Serum
Thrombopoiesis
Cyclosporine
Blood Platelets
Immunoglobulin G
Antibodies
Therapeutics

Keywords

  • Cyclic amegakaryocytosis
  • Cyclosporin A
  • Immune thrombocytopenia
  • Thrombopoietin

ASJC Scopus subject areas

  • Hematology

Cite this

Zent, C. S., Ratajczak, J., Ratajczak, M. Z., Anastasi, J., Hoffman, P. C., & Gewirtz, A. M. (1999). Relationship between megakaryocyte mass and serum thrombopoietin levels as revealed by a case of cyclic amegakaryocytic thrombocytopenic purpura. British Journal of Haematology, 105(2), 452-458.

Relationship between megakaryocyte mass and serum thrombopoietin levels as revealed by a case of cyclic amegakaryocytic thrombocytopenic purpura. / Zent, Clive S.; Ratajczak, Janina; Ratajczak, Mariusz Z.; Anastasi, John; Hoffman, Philip C.; Gewirtz, Alan M.

In: British Journal of Haematology, Vol. 105, No. 2, 1999, p. 452-458.

Research output: Contribution to journalArticle

Zent, CS, Ratajczak, J, Ratajczak, MZ, Anastasi, J, Hoffman, PC & Gewirtz, AM 1999, 'Relationship between megakaryocyte mass and serum thrombopoietin levels as revealed by a case of cyclic amegakaryocytic thrombocytopenic purpura', British Journal of Haematology, vol. 105, no. 2, pp. 452-458.
Zent, Clive S. ; Ratajczak, Janina ; Ratajczak, Mariusz Z. ; Anastasi, John ; Hoffman, Philip C. ; Gewirtz, Alan M. / Relationship between megakaryocyte mass and serum thrombopoietin levels as revealed by a case of cyclic amegakaryocytic thrombocytopenic purpura. In: British Journal of Haematology. 1999 ; Vol. 105, No. 2. pp. 452-458.
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