Relationship between lung function impairment and health-related quality of life in COPD and interstitial lung disease

Cristine E. Berry, M. Bradley Drummond, MeiLan K. Han, Daner Li, Cathy Fuller, Andrew Harold Limper, Fernando J. Martinez, Marvin I. Schwarz, Frank C. Sciurba, Robert A. Wise

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: Health-related quality-of-life (HRQL) measures have been correlated with lung function in patients with COPD and interstitial lung disease (ILD). However, different pathophysiologic mechanisms may influence how these distinct diseases affect HRQL, resulting in differing HRQL by pulmonary diagnosis among patients with similar severity of ventilatory impairment. Methods: The National Heart, Lung, and Blood Institute Lung Tissue Research Consortium provided data on well-characterized participants with COPD (n = 576) and ILD (n = 405) at four clinical sites. Using multiple linear regression, we examined the effects of FEV1 (% predicted) and diagnosis (ILD vs COPD) on HRQL scores, including total St. George Respiratory Questionnaire (SGRQ) scores and Short Form-12 (SF-12) physical component summary (PCS) and mental component summary (MCS) scores. Results: Participants with ILD had, on average, higher SGRQ scores (15.33 points; 95% CI, 12.46-18.19; P <.001) and lower SF-12 PCS scores (-4.73 points;95% CI, -6.31 to -3.14; P <.001) compared with patients with COPD with similar FEV1 % predicted values, indicating worse HRQL. The specific diagnosis also modified the effect of FEV1 on the total SGRQ score (P =.003) and the SF-12 PCS score (P =.03). There was no relationship between lung function and SF-12 MCS scores. Conclusions: HRQL scores were worse for patients with ILD compared with patients with COPD with similar degrees of ventilatory impairment. Differences in dyspnea mechanism or in the rate of disease progression may account for these differences in HRQL.

Original languageEnglish (US)
Pages (from-to)704-711
Number of pages8
JournalChest
Volume142
Issue number3
DOIs
StatePublished - Sep 2012

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Interstitial Lung Diseases
Chronic Obstructive Pulmonary Disease
Quality of Life
Lung
National Heart, Lung, and Blood Institute (U.S.)
Dyspnea
Disease Progression
Linear Models
Research
Surveys and Questionnaires

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Relationship between lung function impairment and health-related quality of life in COPD and interstitial lung disease. / Berry, Cristine E.; Drummond, M. Bradley; Han, MeiLan K.; Li, Daner; Fuller, Cathy; Limper, Andrew Harold; Martinez, Fernando J.; Schwarz, Marvin I.; Sciurba, Frank C.; Wise, Robert A.

In: Chest, Vol. 142, No. 3, 09.2012, p. 704-711.

Research output: Contribution to journalArticle

Berry, CE, Drummond, MB, Han, MK, Li, D, Fuller, C, Limper, AH, Martinez, FJ, Schwarz, MI, Sciurba, FC & Wise, RA 2012, 'Relationship between lung function impairment and health-related quality of life in COPD and interstitial lung disease', Chest, vol. 142, no. 3, pp. 704-711. https://doi.org/10.1378/chest.11-1332
Berry, Cristine E. ; Drummond, M. Bradley ; Han, MeiLan K. ; Li, Daner ; Fuller, Cathy ; Limper, Andrew Harold ; Martinez, Fernando J. ; Schwarz, Marvin I. ; Sciurba, Frank C. ; Wise, Robert A. / Relationship between lung function impairment and health-related quality of life in COPD and interstitial lung disease. In: Chest. 2012 ; Vol. 142, No. 3. pp. 704-711.
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abstract = "Background: Health-related quality-of-life (HRQL) measures have been correlated with lung function in patients with COPD and interstitial lung disease (ILD). However, different pathophysiologic mechanisms may influence how these distinct diseases affect HRQL, resulting in differing HRQL by pulmonary diagnosis among patients with similar severity of ventilatory impairment. Methods: The National Heart, Lung, and Blood Institute Lung Tissue Research Consortium provided data on well-characterized participants with COPD (n = 576) and ILD (n = 405) at four clinical sites. Using multiple linear regression, we examined the effects of FEV1 ({\%} predicted) and diagnosis (ILD vs COPD) on HRQL scores, including total St. George Respiratory Questionnaire (SGRQ) scores and Short Form-12 (SF-12) physical component summary (PCS) and mental component summary (MCS) scores. Results: Participants with ILD had, on average, higher SGRQ scores (15.33 points; 95{\%} CI, 12.46-18.19; P <.001) and lower SF-12 PCS scores (-4.73 points;95{\%} CI, -6.31 to -3.14; P <.001) compared with patients with COPD with similar FEV1 {\%} predicted values, indicating worse HRQL. The specific diagnosis also modified the effect of FEV1 on the total SGRQ score (P =.003) and the SF-12 PCS score (P =.03). There was no relationship between lung function and SF-12 MCS scores. Conclusions: HRQL scores were worse for patients with ILD compared with patients with COPD with similar degrees of ventilatory impairment. Differences in dyspnea mechanism or in the rate of disease progression may account for these differences in HRQL.",
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AU - Berry, Cristine E.

AU - Drummond, M. Bradley

AU - Han, MeiLan K.

AU - Li, Daner

AU - Fuller, Cathy

AU - Limper, Andrew Harold

AU - Martinez, Fernando J.

AU - Schwarz, Marvin I.

AU - Sciurba, Frank C.

AU - Wise, Robert A.

PY - 2012/9

Y1 - 2012/9

N2 - Background: Health-related quality-of-life (HRQL) measures have been correlated with lung function in patients with COPD and interstitial lung disease (ILD). However, different pathophysiologic mechanisms may influence how these distinct diseases affect HRQL, resulting in differing HRQL by pulmonary diagnosis among patients with similar severity of ventilatory impairment. Methods: The National Heart, Lung, and Blood Institute Lung Tissue Research Consortium provided data on well-characterized participants with COPD (n = 576) and ILD (n = 405) at four clinical sites. Using multiple linear regression, we examined the effects of FEV1 (% predicted) and diagnosis (ILD vs COPD) on HRQL scores, including total St. George Respiratory Questionnaire (SGRQ) scores and Short Form-12 (SF-12) physical component summary (PCS) and mental component summary (MCS) scores. Results: Participants with ILD had, on average, higher SGRQ scores (15.33 points; 95% CI, 12.46-18.19; P <.001) and lower SF-12 PCS scores (-4.73 points;95% CI, -6.31 to -3.14; P <.001) compared with patients with COPD with similar FEV1 % predicted values, indicating worse HRQL. The specific diagnosis also modified the effect of FEV1 on the total SGRQ score (P =.003) and the SF-12 PCS score (P =.03). There was no relationship between lung function and SF-12 MCS scores. Conclusions: HRQL scores were worse for patients with ILD compared with patients with COPD with similar degrees of ventilatory impairment. Differences in dyspnea mechanism or in the rate of disease progression may account for these differences in HRQL.

AB - Background: Health-related quality-of-life (HRQL) measures have been correlated with lung function in patients with COPD and interstitial lung disease (ILD). However, different pathophysiologic mechanisms may influence how these distinct diseases affect HRQL, resulting in differing HRQL by pulmonary diagnosis among patients with similar severity of ventilatory impairment. Methods: The National Heart, Lung, and Blood Institute Lung Tissue Research Consortium provided data on well-characterized participants with COPD (n = 576) and ILD (n = 405) at four clinical sites. Using multiple linear regression, we examined the effects of FEV1 (% predicted) and diagnosis (ILD vs COPD) on HRQL scores, including total St. George Respiratory Questionnaire (SGRQ) scores and Short Form-12 (SF-12) physical component summary (PCS) and mental component summary (MCS) scores. Results: Participants with ILD had, on average, higher SGRQ scores (15.33 points; 95% CI, 12.46-18.19; P <.001) and lower SF-12 PCS scores (-4.73 points;95% CI, -6.31 to -3.14; P <.001) compared with patients with COPD with similar FEV1 % predicted values, indicating worse HRQL. The specific diagnosis also modified the effect of FEV1 on the total SGRQ score (P =.003) and the SF-12 PCS score (P =.03). There was no relationship between lung function and SF-12 MCS scores. Conclusions: HRQL scores were worse for patients with ILD compared with patients with COPD with similar degrees of ventilatory impairment. Differences in dyspnea mechanism or in the rate of disease progression may account for these differences in HRQL.

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U2 - 10.1378/chest.11-1332

DO - 10.1378/chest.11-1332

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JO - Chest

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