Relationship between left ventricular wall stress and ANP gene expression during the evolution of rapid ventricular pacing-induced heart failure in the dog

A. Luchner, Daniel Dean Borgeson, J. A. Grantham, E. Friedrich, G. A J Riegger, John C Jr. Burnett, Margaret May Redfield

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We have recently described a modified model of progressive rapid ventricular pacing-induced heart failure which evolves over a period of 38 days. To further characterize left ventricular remodeling during the progression of heart failure, we assessed left ventricular geometry, wall stress, and atrial natriuretic peptide (ANP) gene expression and protein content during control conditions, asymptomatic left ventricular dysfunction, and overt congestive heart failure (CHF). Although asymptomatic left ventricular dysfunction was characterized by a significant increase in systolic and diastolic left ventricular dimension (+30% and +6%, respectively, P < 0.05 each) and a marked increase in left ventricular systolic wall stress (+68%, P < 0.01), left ventricular ANP gene expression was unchanged as compared to control. In contrast, strong left ventricular ANP gene expression (+449%, P < 0.05) was observed during overt CHF in the absence of further significant increases in left ventricular systolic wall stress. The onset of strong left ventricular ANP gene expression was associated with increased ANP content (+88%, P < 0.05) and left ventricular mass index (+13%, P < 0.05). In contrast, left atrial ANP gene expression and left ventricular diastolic wall stress increased progressively during asymptomatic left ventricular dysfunction (+39%, P = n.s. and +131%, P < 0.01) and overt CHF (+76% and +336% vs. control, P < 0.01 each). Progressive rapid ventricular pacing is associated with the induction of left ventricular ANP gene expression and protein synthesis exclusively during overt CHF. The current studies provide new insight into the temporal pattern of ANP-activation and the disparity between left ventricular systolic wall stress and ANP-activation in a large animal model of progressive CHF. (C) European Society of Cardiology.

Original languageEnglish (US)
Pages (from-to)379-386
Number of pages8
JournalEuropean Journal of Heart Failure
Volume2
Issue number4
DOIs
StatePublished - 2000

Fingerprint

Atrial Natriuretic Factor
Heart Failure
Dogs
Gene Expression
Left Ventricular Dysfunction
Asymptomatic Diseases
Ventricular Remodeling
Proteins
Animal Models

Keywords

  • Dog
  • Gene
  • LV hypertrophy
  • Pacing

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

@article{3d50696e803a4254a4216608e2162740,
title = "Relationship between left ventricular wall stress and ANP gene expression during the evolution of rapid ventricular pacing-induced heart failure in the dog",
abstract = "We have recently described a modified model of progressive rapid ventricular pacing-induced heart failure which evolves over a period of 38 days. To further characterize left ventricular remodeling during the progression of heart failure, we assessed left ventricular geometry, wall stress, and atrial natriuretic peptide (ANP) gene expression and protein content during control conditions, asymptomatic left ventricular dysfunction, and overt congestive heart failure (CHF). Although asymptomatic left ventricular dysfunction was characterized by a significant increase in systolic and diastolic left ventricular dimension (+30{\%} and +6{\%}, respectively, P < 0.05 each) and a marked increase in left ventricular systolic wall stress (+68{\%}, P < 0.01), left ventricular ANP gene expression was unchanged as compared to control. In contrast, strong left ventricular ANP gene expression (+449{\%}, P < 0.05) was observed during overt CHF in the absence of further significant increases in left ventricular systolic wall stress. The onset of strong left ventricular ANP gene expression was associated with increased ANP content (+88{\%}, P < 0.05) and left ventricular mass index (+13{\%}, P < 0.05). In contrast, left atrial ANP gene expression and left ventricular diastolic wall stress increased progressively during asymptomatic left ventricular dysfunction (+39{\%}, P = n.s. and +131{\%}, P < 0.01) and overt CHF (+76{\%} and +336{\%} vs. control, P < 0.01 each). Progressive rapid ventricular pacing is associated with the induction of left ventricular ANP gene expression and protein synthesis exclusively during overt CHF. The current studies provide new insight into the temporal pattern of ANP-activation and the disparity between left ventricular systolic wall stress and ANP-activation in a large animal model of progressive CHF. (C) European Society of Cardiology.",
keywords = "Dog, Gene, LV hypertrophy, Pacing",
author = "A. Luchner and Borgeson, {Daniel Dean} and Grantham, {J. A.} and E. Friedrich and Riegger, {G. A J} and Burnett, {John C Jr.} and Redfield, {Margaret May}",
year = "2000",
doi = "10.1016/S1388-9842(00)00104-5",
language = "English (US)",
volume = "2",
pages = "379--386",
journal = "European Journal of Heart Failure",
issn = "1388-9842",
publisher = "Oxford University Press",
number = "4",

}

TY - JOUR

T1 - Relationship between left ventricular wall stress and ANP gene expression during the evolution of rapid ventricular pacing-induced heart failure in the dog

AU - Luchner, A.

AU - Borgeson, Daniel Dean

AU - Grantham, J. A.

AU - Friedrich, E.

AU - Riegger, G. A J

AU - Burnett, John C Jr.

AU - Redfield, Margaret May

PY - 2000

Y1 - 2000

N2 - We have recently described a modified model of progressive rapid ventricular pacing-induced heart failure which evolves over a period of 38 days. To further characterize left ventricular remodeling during the progression of heart failure, we assessed left ventricular geometry, wall stress, and atrial natriuretic peptide (ANP) gene expression and protein content during control conditions, asymptomatic left ventricular dysfunction, and overt congestive heart failure (CHF). Although asymptomatic left ventricular dysfunction was characterized by a significant increase in systolic and diastolic left ventricular dimension (+30% and +6%, respectively, P < 0.05 each) and a marked increase in left ventricular systolic wall stress (+68%, P < 0.01), left ventricular ANP gene expression was unchanged as compared to control. In contrast, strong left ventricular ANP gene expression (+449%, P < 0.05) was observed during overt CHF in the absence of further significant increases in left ventricular systolic wall stress. The onset of strong left ventricular ANP gene expression was associated with increased ANP content (+88%, P < 0.05) and left ventricular mass index (+13%, P < 0.05). In contrast, left atrial ANP gene expression and left ventricular diastolic wall stress increased progressively during asymptomatic left ventricular dysfunction (+39%, P = n.s. and +131%, P < 0.01) and overt CHF (+76% and +336% vs. control, P < 0.01 each). Progressive rapid ventricular pacing is associated with the induction of left ventricular ANP gene expression and protein synthesis exclusively during overt CHF. The current studies provide new insight into the temporal pattern of ANP-activation and the disparity between left ventricular systolic wall stress and ANP-activation in a large animal model of progressive CHF. (C) European Society of Cardiology.

AB - We have recently described a modified model of progressive rapid ventricular pacing-induced heart failure which evolves over a period of 38 days. To further characterize left ventricular remodeling during the progression of heart failure, we assessed left ventricular geometry, wall stress, and atrial natriuretic peptide (ANP) gene expression and protein content during control conditions, asymptomatic left ventricular dysfunction, and overt congestive heart failure (CHF). Although asymptomatic left ventricular dysfunction was characterized by a significant increase in systolic and diastolic left ventricular dimension (+30% and +6%, respectively, P < 0.05 each) and a marked increase in left ventricular systolic wall stress (+68%, P < 0.01), left ventricular ANP gene expression was unchanged as compared to control. In contrast, strong left ventricular ANP gene expression (+449%, P < 0.05) was observed during overt CHF in the absence of further significant increases in left ventricular systolic wall stress. The onset of strong left ventricular ANP gene expression was associated with increased ANP content (+88%, P < 0.05) and left ventricular mass index (+13%, P < 0.05). In contrast, left atrial ANP gene expression and left ventricular diastolic wall stress increased progressively during asymptomatic left ventricular dysfunction (+39%, P = n.s. and +131%, P < 0.01) and overt CHF (+76% and +336% vs. control, P < 0.01 each). Progressive rapid ventricular pacing is associated with the induction of left ventricular ANP gene expression and protein synthesis exclusively during overt CHF. The current studies provide new insight into the temporal pattern of ANP-activation and the disparity between left ventricular systolic wall stress and ANP-activation in a large animal model of progressive CHF. (C) European Society of Cardiology.

KW - Dog

KW - Gene

KW - LV hypertrophy

KW - Pacing

UR - http://www.scopus.com/inward/record.url?scp=0034537368&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034537368&partnerID=8YFLogxK

U2 - 10.1016/S1388-9842(00)00104-5

DO - 10.1016/S1388-9842(00)00104-5

M3 - Article

VL - 2

SP - 379

EP - 386

JO - European Journal of Heart Failure

JF - European Journal of Heart Failure

SN - 1388-9842

IS - 4

ER -