Relationship between interferon regulatory factor 4 genetic polymorphisms, measures of sun sensitivity and risk for non-Hodgkin lymphoma.

Allison H. Gathany, Patricia Hartge, Scott Davis, James R Cerhan, Richard K. Severson, Wendy Cozen, Nathaniel Rothman, Stephen J. Chanock, Sophia S. Wang

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

OBJECTIVE: Sun exposure and sensitivity, including pigmentation, are associated with risk for non-Hodgkin lymphoma (NHL). One variant in the immune regulatory factor 4 (IRF4) gene (rs12203592) is associated with pigmentation, and a different IRF4 variant (rs12211228) is associated with NHL risk. We evaluated the independent roles of these IRF4 polymorphisms and sun sensitivity in mediating NHL risk and explored whether they are confounded or modified by each other. METHODS: Genotyping of tag single nucleotide polymorphisms (SNPs) in the IRF4 gene was conducted in 990 NHL cases and 828 controls from a multi-center US study. Measures of sun sensitivity and exposure were ascertained from computer-assisted personal interviews. We used logistic regression to compute odds ratios (OR) and 95% confidence intervals (CI) for NHL in relation to sun exposures, sun exposures in relation to IRF4 genotypes, and NHL in relation to sun exposures. We further assessed the effects of sun exposures in relation to IRF4 genotypes. RESULTS: As previously reported, we found significant associations between IRF4 rs12211228 and NHL and between hair and eye color and NHL. The IRF4 rs12203592 polymorphism (CT/TT genotype) was statistically significantly associated with eye color and particularly with hair color (OR(Light Blonde) = 0.24, 95% CI = 0.11-0.50, overall Chi square p = 0.0002). Analysis of joint effects between eye and hair color with the IRF4 rs12203592 SNP did not reveal statistically significant p-interactions although NHL risk did decline with lighter hair color and presence of the variant IRF4 rs12203592 allele, compared to those without a variant allele and with black/brown hair color. CONCLUSIONS: Our data do not statistically support a joint effect between IRF4 and sun sensitivity in mediating risk for NHL. Further evaluation of joint effects in other and larger populations is warranted.

Original languageEnglish (US)
Pages (from-to)1291-1302
Number of pages12
JournalCancer causes & control : CCC
Volume20
Issue number8
DOIs
StatePublished - Oct 2009

Fingerprint

Immunologic Factors
Solar System
Genetic Polymorphisms
Non-Hodgkin's Lymphoma
Hair Color
Eye Color
Genotype
Pigmentation
Single Nucleotide Polymorphism
interferon regulatory factor-4
Alleles
Odds Ratio
Confidence Intervals
Microcomputers
Genes
Logistic Models
Interviews
Light

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Relationship between interferon regulatory factor 4 genetic polymorphisms, measures of sun sensitivity and risk for non-Hodgkin lymphoma. / Gathany, Allison H.; Hartge, Patricia; Davis, Scott; Cerhan, James R; Severson, Richard K.; Cozen, Wendy; Rothman, Nathaniel; Chanock, Stephen J.; Wang, Sophia S.

In: Cancer causes & control : CCC, Vol. 20, No. 8, 10.2009, p. 1291-1302.

Research output: Contribution to journalArticle

Gathany, Allison H. ; Hartge, Patricia ; Davis, Scott ; Cerhan, James R ; Severson, Richard K. ; Cozen, Wendy ; Rothman, Nathaniel ; Chanock, Stephen J. ; Wang, Sophia S. / Relationship between interferon regulatory factor 4 genetic polymorphisms, measures of sun sensitivity and risk for non-Hodgkin lymphoma. In: Cancer causes & control : CCC. 2009 ; Vol. 20, No. 8. pp. 1291-1302.
@article{a19d20025c62468694721ac74772cb9a,
title = "Relationship between interferon regulatory factor 4 genetic polymorphisms, measures of sun sensitivity and risk for non-Hodgkin lymphoma.",
abstract = "OBJECTIVE: Sun exposure and sensitivity, including pigmentation, are associated with risk for non-Hodgkin lymphoma (NHL). One variant in the immune regulatory factor 4 (IRF4) gene (rs12203592) is associated with pigmentation, and a different IRF4 variant (rs12211228) is associated with NHL risk. We evaluated the independent roles of these IRF4 polymorphisms and sun sensitivity in mediating NHL risk and explored whether they are confounded or modified by each other. METHODS: Genotyping of tag single nucleotide polymorphisms (SNPs) in the IRF4 gene was conducted in 990 NHL cases and 828 controls from a multi-center US study. Measures of sun sensitivity and exposure were ascertained from computer-assisted personal interviews. We used logistic regression to compute odds ratios (OR) and 95{\%} confidence intervals (CI) for NHL in relation to sun exposures, sun exposures in relation to IRF4 genotypes, and NHL in relation to sun exposures. We further assessed the effects of sun exposures in relation to IRF4 genotypes. RESULTS: As previously reported, we found significant associations between IRF4 rs12211228 and NHL and between hair and eye color and NHL. The IRF4 rs12203592 polymorphism (CT/TT genotype) was statistically significantly associated with eye color and particularly with hair color (OR(Light Blonde) = 0.24, 95{\%} CI = 0.11-0.50, overall Chi square p = 0.0002). Analysis of joint effects between eye and hair color with the IRF4 rs12203592 SNP did not reveal statistically significant p-interactions although NHL risk did decline with lighter hair color and presence of the variant IRF4 rs12203592 allele, compared to those without a variant allele and with black/brown hair color. CONCLUSIONS: Our data do not statistically support a joint effect between IRF4 and sun sensitivity in mediating risk for NHL. Further evaluation of joint effects in other and larger populations is warranted.",
author = "Gathany, {Allison H.} and Patricia Hartge and Scott Davis and Cerhan, {James R} and Severson, {Richard K.} and Wendy Cozen and Nathaniel Rothman and Chanock, {Stephen J.} and Wang, {Sophia S.}",
year = "2009",
month = "10",
doi = "10.1007/s10552-009-9348-5",
language = "English (US)",
volume = "20",
pages = "1291--1302",
journal = "Cancer Causes and Control",
issn = "0957-5243",
publisher = "Springer Netherlands",
number = "8",

}

TY - JOUR

T1 - Relationship between interferon regulatory factor 4 genetic polymorphisms, measures of sun sensitivity and risk for non-Hodgkin lymphoma.

AU - Gathany, Allison H.

AU - Hartge, Patricia

AU - Davis, Scott

AU - Cerhan, James R

AU - Severson, Richard K.

AU - Cozen, Wendy

AU - Rothman, Nathaniel

AU - Chanock, Stephen J.

AU - Wang, Sophia S.

PY - 2009/10

Y1 - 2009/10

N2 - OBJECTIVE: Sun exposure and sensitivity, including pigmentation, are associated with risk for non-Hodgkin lymphoma (NHL). One variant in the immune regulatory factor 4 (IRF4) gene (rs12203592) is associated with pigmentation, and a different IRF4 variant (rs12211228) is associated with NHL risk. We evaluated the independent roles of these IRF4 polymorphisms and sun sensitivity in mediating NHL risk and explored whether they are confounded or modified by each other. METHODS: Genotyping of tag single nucleotide polymorphisms (SNPs) in the IRF4 gene was conducted in 990 NHL cases and 828 controls from a multi-center US study. Measures of sun sensitivity and exposure were ascertained from computer-assisted personal interviews. We used logistic regression to compute odds ratios (OR) and 95% confidence intervals (CI) for NHL in relation to sun exposures, sun exposures in relation to IRF4 genotypes, and NHL in relation to sun exposures. We further assessed the effects of sun exposures in relation to IRF4 genotypes. RESULTS: As previously reported, we found significant associations between IRF4 rs12211228 and NHL and between hair and eye color and NHL. The IRF4 rs12203592 polymorphism (CT/TT genotype) was statistically significantly associated with eye color and particularly with hair color (OR(Light Blonde) = 0.24, 95% CI = 0.11-0.50, overall Chi square p = 0.0002). Analysis of joint effects between eye and hair color with the IRF4 rs12203592 SNP did not reveal statistically significant p-interactions although NHL risk did decline with lighter hair color and presence of the variant IRF4 rs12203592 allele, compared to those without a variant allele and with black/brown hair color. CONCLUSIONS: Our data do not statistically support a joint effect between IRF4 and sun sensitivity in mediating risk for NHL. Further evaluation of joint effects in other and larger populations is warranted.

AB - OBJECTIVE: Sun exposure and sensitivity, including pigmentation, are associated with risk for non-Hodgkin lymphoma (NHL). One variant in the immune regulatory factor 4 (IRF4) gene (rs12203592) is associated with pigmentation, and a different IRF4 variant (rs12211228) is associated with NHL risk. We evaluated the independent roles of these IRF4 polymorphisms and sun sensitivity in mediating NHL risk and explored whether they are confounded or modified by each other. METHODS: Genotyping of tag single nucleotide polymorphisms (SNPs) in the IRF4 gene was conducted in 990 NHL cases and 828 controls from a multi-center US study. Measures of sun sensitivity and exposure were ascertained from computer-assisted personal interviews. We used logistic regression to compute odds ratios (OR) and 95% confidence intervals (CI) for NHL in relation to sun exposures, sun exposures in relation to IRF4 genotypes, and NHL in relation to sun exposures. We further assessed the effects of sun exposures in relation to IRF4 genotypes. RESULTS: As previously reported, we found significant associations between IRF4 rs12211228 and NHL and between hair and eye color and NHL. The IRF4 rs12203592 polymorphism (CT/TT genotype) was statistically significantly associated with eye color and particularly with hair color (OR(Light Blonde) = 0.24, 95% CI = 0.11-0.50, overall Chi square p = 0.0002). Analysis of joint effects between eye and hair color with the IRF4 rs12203592 SNP did not reveal statistically significant p-interactions although NHL risk did decline with lighter hair color and presence of the variant IRF4 rs12203592 allele, compared to those without a variant allele and with black/brown hair color. CONCLUSIONS: Our data do not statistically support a joint effect between IRF4 and sun sensitivity in mediating risk for NHL. Further evaluation of joint effects in other and larger populations is warranted.

UR - http://www.scopus.com/inward/record.url?scp=77953624982&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953624982&partnerID=8YFLogxK

U2 - 10.1007/s10552-009-9348-5

DO - 10.1007/s10552-009-9348-5

M3 - Article

C2 - 19396635

AN - SCOPUS:77953624982

VL - 20

SP - 1291

EP - 1302

JO - Cancer Causes and Control

JF - Cancer Causes and Control

SN - 0957-5243

IS - 8

ER -