Relationship between insulin sensitivity and long-term weight change in adults

Aaron M. Potretzke, Meghan Warren, Kathryn H. Schmitz, Tara S. Gottsacker, Michael Dennis Jensen

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: To determine whether insulin resistance is associated with reduced risk of weight gain. Methods: In this retrospective study, we reviewed medical records of volunteers who had undergone a euglycemic, hyperinsulinemic clamp in research studies at Mayo Clinic between October 20, 1986, and January 30, 2002. Data from volunteers who had at least 1 year of follow-up were analyzed, which included height, weight, date of birth, ethnicity, body composition (percentage body fat and kilograms of fat-free mass), waist-to-hip ratio, date of insulin clamp, fasting plasma glucose and insulin, average plasma glucose and insulin concentrations during the final 30 minutes of each insulin clamp step, and average glucose infusion rate (μmol·kg fat free mass-1·min-1) during the final 30 minutes of each insulin clamp step. We abstracted the following for each medical encounter: date of visit, height, weight, diagnoses, procedures, and medication use. For the purposes of statistical analysis, the diagnoses, procedures, and medications were then converted into Current Procedural Terminology codes and National Drug Codes. Results: One hundred sixteen patients had at least 1 year of follow-up. The average baseline body mass index was 29.4 ± 5.3 kg/m2, and the follow-up time averaged 8.1 ± 5.9 years. We found no significant correlation between baseline insulin action and annual weight change or overall weight change (P = .60 and P = .11, respectively) or between log-transformed insulin action and annual weight gain (P = .61). Conclusion: These results suggest that in free-living, healthy, white adults, there is not a clinically meaningful relationship between insulin action and subsequent weight change.

Original languageEnglish (US)
Pages (from-to)58-64
Number of pages7
JournalEndocrine Practice
Volume17
Issue number1
DOIs
StatePublished - Jan 2011

Fingerprint

Insulin Resistance
Insulin
Weights and Measures
Glucose
Weight Gain
Volunteers
Fats
Current Procedural Terminology
Glucose Clamp Technique
Waist-Hip Ratio
Body Composition
Birth Weight
Medical Records
Adipose Tissue
Fasting
Body Mass Index
Retrospective Studies
Research
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Relationship between insulin sensitivity and long-term weight change in adults. / Potretzke, Aaron M.; Warren, Meghan; Schmitz, Kathryn H.; Gottsacker, Tara S.; Jensen, Michael Dennis.

In: Endocrine Practice, Vol. 17, No. 1, 01.2011, p. 58-64.

Research output: Contribution to journalArticle

Potretzke, Aaron M. ; Warren, Meghan ; Schmitz, Kathryn H. ; Gottsacker, Tara S. ; Jensen, Michael Dennis. / Relationship between insulin sensitivity and long-term weight change in adults. In: Endocrine Practice. 2011 ; Vol. 17, No. 1. pp. 58-64.
@article{4b4c904354c24390b79e20f41be398a7,
title = "Relationship between insulin sensitivity and long-term weight change in adults",
abstract = "Objective: To determine whether insulin resistance is associated with reduced risk of weight gain. Methods: In this retrospective study, we reviewed medical records of volunteers who had undergone a euglycemic, hyperinsulinemic clamp in research studies at Mayo Clinic between October 20, 1986, and January 30, 2002. Data from volunteers who had at least 1 year of follow-up were analyzed, which included height, weight, date of birth, ethnicity, body composition (percentage body fat and kilograms of fat-free mass), waist-to-hip ratio, date of insulin clamp, fasting plasma glucose and insulin, average plasma glucose and insulin concentrations during the final 30 minutes of each insulin clamp step, and average glucose infusion rate (μmol·kg fat free mass-1·min-1) during the final 30 minutes of each insulin clamp step. We abstracted the following for each medical encounter: date of visit, height, weight, diagnoses, procedures, and medication use. For the purposes of statistical analysis, the diagnoses, procedures, and medications were then converted into Current Procedural Terminology codes and National Drug Codes. Results: One hundred sixteen patients had at least 1 year of follow-up. The average baseline body mass index was 29.4 ± 5.3 kg/m2, and the follow-up time averaged 8.1 ± 5.9 years. We found no significant correlation between baseline insulin action and annual weight change or overall weight change (P = .60 and P = .11, respectively) or between log-transformed insulin action and annual weight gain (P = .61). Conclusion: These results suggest that in free-living, healthy, white adults, there is not a clinically meaningful relationship between insulin action and subsequent weight change.",
author = "Potretzke, {Aaron M.} and Meghan Warren and Schmitz, {Kathryn H.} and Gottsacker, {Tara S.} and Jensen, {Michael Dennis}",
year = "2011",
month = "1",
doi = "10.4158/EP10172.OR",
language = "English (US)",
volume = "17",
pages = "58--64",
journal = "Endocrine Practice",
issn = "1530-891X",
publisher = "American Association of Clinical Endocrinology",
number = "1",

}

TY - JOUR

T1 - Relationship between insulin sensitivity and long-term weight change in adults

AU - Potretzke, Aaron M.

AU - Warren, Meghan

AU - Schmitz, Kathryn H.

AU - Gottsacker, Tara S.

AU - Jensen, Michael Dennis

PY - 2011/1

Y1 - 2011/1

N2 - Objective: To determine whether insulin resistance is associated with reduced risk of weight gain. Methods: In this retrospective study, we reviewed medical records of volunteers who had undergone a euglycemic, hyperinsulinemic clamp in research studies at Mayo Clinic between October 20, 1986, and January 30, 2002. Data from volunteers who had at least 1 year of follow-up were analyzed, which included height, weight, date of birth, ethnicity, body composition (percentage body fat and kilograms of fat-free mass), waist-to-hip ratio, date of insulin clamp, fasting plasma glucose and insulin, average plasma glucose and insulin concentrations during the final 30 minutes of each insulin clamp step, and average glucose infusion rate (μmol·kg fat free mass-1·min-1) during the final 30 minutes of each insulin clamp step. We abstracted the following for each medical encounter: date of visit, height, weight, diagnoses, procedures, and medication use. For the purposes of statistical analysis, the diagnoses, procedures, and medications were then converted into Current Procedural Terminology codes and National Drug Codes. Results: One hundred sixteen patients had at least 1 year of follow-up. The average baseline body mass index was 29.4 ± 5.3 kg/m2, and the follow-up time averaged 8.1 ± 5.9 years. We found no significant correlation between baseline insulin action and annual weight change or overall weight change (P = .60 and P = .11, respectively) or between log-transformed insulin action and annual weight gain (P = .61). Conclusion: These results suggest that in free-living, healthy, white adults, there is not a clinically meaningful relationship between insulin action and subsequent weight change.

AB - Objective: To determine whether insulin resistance is associated with reduced risk of weight gain. Methods: In this retrospective study, we reviewed medical records of volunteers who had undergone a euglycemic, hyperinsulinemic clamp in research studies at Mayo Clinic between October 20, 1986, and January 30, 2002. Data from volunteers who had at least 1 year of follow-up were analyzed, which included height, weight, date of birth, ethnicity, body composition (percentage body fat and kilograms of fat-free mass), waist-to-hip ratio, date of insulin clamp, fasting plasma glucose and insulin, average plasma glucose and insulin concentrations during the final 30 minutes of each insulin clamp step, and average glucose infusion rate (μmol·kg fat free mass-1·min-1) during the final 30 minutes of each insulin clamp step. We abstracted the following for each medical encounter: date of visit, height, weight, diagnoses, procedures, and medication use. For the purposes of statistical analysis, the diagnoses, procedures, and medications were then converted into Current Procedural Terminology codes and National Drug Codes. Results: One hundred sixteen patients had at least 1 year of follow-up. The average baseline body mass index was 29.4 ± 5.3 kg/m2, and the follow-up time averaged 8.1 ± 5.9 years. We found no significant correlation between baseline insulin action and annual weight change or overall weight change (P = .60 and P = .11, respectively) or between log-transformed insulin action and annual weight gain (P = .61). Conclusion: These results suggest that in free-living, healthy, white adults, there is not a clinically meaningful relationship between insulin action and subsequent weight change.

UR - http://www.scopus.com/inward/record.url?scp=79952395736&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952395736&partnerID=8YFLogxK

U2 - 10.4158/EP10172.OR

DO - 10.4158/EP10172.OR

M3 - Article

C2 - 20713336

AN - SCOPUS:79952395736

VL - 17

SP - 58

EP - 64

JO - Endocrine Practice

JF - Endocrine Practice

SN - 1530-891X

IS - 1

ER -