Relationship between HLA polymorphisms and gamma interferon and interleukin-10 cytokine production in healthy individuals after rubella vaccination

Inna G. Ovsyannikova, Robert M. Jacobson, Jenna E. Ryan, Neelam Dhiman, Robert A. Vierkant, Gregory A. Poland

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

We studied the association between HLA alleles and rubella-specific gamma interferon (IFN-γ) (Th1) and interleukin-10 (IL-10) (Th2) cytokine responses among 106 healthy children (ages, 14 to 17 years) previously immunized with two doses of rubella vaccine. Antibody titers and cytokine responses to rubella vaccination were not sex or age dependent. Several class I HLA-A (*0201, *2402, *6801) alleles were significantly associated with rubella vaccine-induced IFN-γ secretion. Several class II HLA-DRB1 (*0101) and HLA-DQB1 (*0501) alleles were also suggestive of an association with IFN-γ secretion. Alleles with potential associations with rubella-specific IL-10 production included HLA-A (*0201, *6801), HLA-B (*4901), and HLA-DRB1 (*1302). The class I A*0201 and A*6801 alleles were associated with both IFN-γ and IL-10 secretion. These tentative associations need to be validated in larger studies with subjects of differing ethnicities. These results provide additional evidence that HLA genes may influence Th1- and Th2-specific cytokine response(s) following rubella immunization, which in turn can influence both cellular and humoral immune responses to rubella vaccination.

Original languageEnglish (US)
Pages (from-to)115-122
Number of pages8
JournalClinical and Vaccine Immunology
Volume14
Issue number2
DOIs
StatePublished - Feb 2007

Fingerprint

Rubella
Polymorphism
Rubella Vaccine
Interleukin-10
Interferon-gamma
HLA-DRB1 Chains
Vaccination
Alleles
Cytokines
Immunization
HLA-B Antigens
Genes
Humoral Immunity
Antibodies
Cellular Immunity
HLA-A*02:01 antigen

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Immunology
  • Immunology and Allergy
  • Microbiology (medical)

Cite this

Relationship between HLA polymorphisms and gamma interferon and interleukin-10 cytokine production in healthy individuals after rubella vaccination. / Ovsyannikova, Inna G.; Jacobson, Robert M.; Ryan, Jenna E.; Dhiman, Neelam; Vierkant, Robert A.; Poland, Gregory A.

In: Clinical and Vaccine Immunology, Vol. 14, No. 2, 02.2007, p. 115-122.

Research output: Contribution to journalArticle

Ovsyannikova, Inna G. ; Jacobson, Robert M. ; Ryan, Jenna E. ; Dhiman, Neelam ; Vierkant, Robert A. ; Poland, Gregory A. / Relationship between HLA polymorphisms and gamma interferon and interleukin-10 cytokine production in healthy individuals after rubella vaccination. In: Clinical and Vaccine Immunology. 2007 ; Vol. 14, No. 2. pp. 115-122.
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