Relationship between glycosylated hemoglobin A1c and coronary flow reserve in patients with Type 2 diabetes mellitus

Runqing Huang, Sahar S. Abdelmoneim, Lara F. Nhola, Rita Basu, Ananda Basu, Sharon L. Mulvagh

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

Type 2 diabetes mellitus patients are at increased risk for macrovascular and microvascular complications. Both in vivo and in vitro studies of small arteries and arterioles of diabetic subjects demonstrate impaired endothelial function without anatomic lesions. Coronary flow reserve (CFR) is a surrogate marker of coronary microcirculatory endothelial function in diabetic patients without significant stenosis of the associated epicardial coronary artery. Glycosylated hemoglobin A1c is related to likelihood of occurrence of microvascular events. The objective of this article is to report on recent developments in multiple noninvasive techniques to assess CFR and their use in aiding the understanding of the relationship of CFR, glycemic control and cardiovascular outcomes.

Original languageEnglish (US)
Pages (from-to)445-453
Number of pages9
JournalExpert Review of Cardiovascular Therapy
Volume13
Issue number4
DOIs
StatePublished - Apr 1 2015

Keywords

  • Type 2 diabetes mellitus
  • coronary flow reserve
  • glycemic control
  • glycosylated hemoglobin A1c
  • noninvasive techniques

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

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