TY - JOUR
T1 - Relationship between exercise heart rate and age in men Vs women
AU - Sydó, Nóra
AU - Abdelmoneim, Sahar S.
AU - Mulvagh, Sharon L.
AU - Merkely, Béla
AU - Gulati, Martha
AU - Allison, Thomas G.
N1 - Funding Information:
Grant Support: The work was supported by the Division of Cardiovascular Diseases and Internal Medicine , Mayo Clinic Rochester, MN.
Publisher Copyright:
© 2014 Mayo Foundation for Medical Education and Research.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Objective To analyze a large cohort of patients who underwent exercise testing and also report sex differences in other exercise heart rate (HR) parameters to determine whether separate sex-based equations to predict peak HR are indicated.Patients and Methods Patients aged 40 to 89 years who performed treadmill exercise tests (Bruce protocol) from September 21, 1993, to December 20, 2010, were included. Patients with cardiovascular disease or taking HR-attenuating drugs were excluded. After analyses on preliminary cohort, peak HR-modifying factors were eliminated to obtain a pure data set. Analysis of variance was used to test difference in HR responses by sex with age adjustment.Results A total of 37,010 patients (67.3% men) were included in the preliminary cohort. Men had higher peak HR (166±17 vs 163±16 beats/min [bpm]; P<.001), HR reserve (90±19 vs 84±17 bpm; P<.001), and HR recovery (19±8 vs 18±9 bpm; P<.03). Poor exercise capacity, current smoking, diabetes, and obesity had significant peak HR-lowering effects (all P<.001). In a pure cohort of 19,013 patients (51.3% of full cohort) without these factors, regression lines approximated more closely the traditional line of 220 - age. For men, the regression line in our final cohort was peak HR = 220 - 0.95 × age. For women, both slope (0.79 bpm/y) and intercept (210 bpm) were still substantially different from those obtained with the traditional formula.Conclusion The HR responses to exercise are different in men and women. The HR response of men was close to that obtained with the traditional formula, but peak HR in women had a lower intercept and decreased more slowly with age. A separate formula for peak HR in women appears to be appropriate.
AB - Objective To analyze a large cohort of patients who underwent exercise testing and also report sex differences in other exercise heart rate (HR) parameters to determine whether separate sex-based equations to predict peak HR are indicated.Patients and Methods Patients aged 40 to 89 years who performed treadmill exercise tests (Bruce protocol) from September 21, 1993, to December 20, 2010, were included. Patients with cardiovascular disease or taking HR-attenuating drugs were excluded. After analyses on preliminary cohort, peak HR-modifying factors were eliminated to obtain a pure data set. Analysis of variance was used to test difference in HR responses by sex with age adjustment.Results A total of 37,010 patients (67.3% men) were included in the preliminary cohort. Men had higher peak HR (166±17 vs 163±16 beats/min [bpm]; P<.001), HR reserve (90±19 vs 84±17 bpm; P<.001), and HR recovery (19±8 vs 18±9 bpm; P<.03). Poor exercise capacity, current smoking, diabetes, and obesity had significant peak HR-lowering effects (all P<.001). In a pure cohort of 19,013 patients (51.3% of full cohort) without these factors, regression lines approximated more closely the traditional line of 220 - age. For men, the regression line in our final cohort was peak HR = 220 - 0.95 × age. For women, both slope (0.79 bpm/y) and intercept (210 bpm) were still substantially different from those obtained with the traditional formula.Conclusion The HR responses to exercise are different in men and women. The HR response of men was close to that obtained with the traditional formula, but peak HR in women had a lower intercept and decreased more slowly with age. A separate formula for peak HR in women appears to be appropriate.
KW - Abbreviations and Acronyms bpm beats/min
KW - ECG electrocardiogram
KW - FAC functional aerobic capacity
KW - HR heart rate
UR - http://www.scopus.com/inward/record.url?scp=84919839784&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84919839784&partnerID=8YFLogxK
U2 - 10.1016/j.mayocp.2014.08.018
DO - 10.1016/j.mayocp.2014.08.018
M3 - Article
C2 - 25441400
AN - SCOPUS:84919839784
SN - 0025-6196
VL - 89
SP - 1664
EP - 1672
JO - Mayo Clinic Proceedings
JF - Mayo Clinic Proceedings
IS - 12
ER -