Relationship between endogenous concentrations of vasoactive substances and measures of peripheral vasodilator function in patients with coronary artery disease

Darren P. Casey, Wilmer W. Nichols, C. Richard Conti, Randy W. Braith

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The aim of the present study was to determine the relationship between plasma concentrations of nitrite/nitrate (NO x) and endothelin (ET)-1 and non-invasive measures of peripheral vasodilator function in patients with coronary artery disease (CAD). Twenty-two patients with angiographic CAD underwent non-invasive measurement of peripheral vasodilator function in the brachial conduit artery (flow-mediated dilation (FMD) testing via ultrasound) and in the forearm resistance arteries (via venous occlusion plethysmography) during reactive hyperaemia after 5 min ischaemia. In addition, plasma NO x and ET-1 concentrations were determined. The plasma concentration of NO x was related to the peak brachial FMD response when expressed as either the relative (%) or absolute (mm) change in diameter (r = 0.73, P < 0.001; and r = 0.64, P < 0.01, respectively). Moreover, plasma concentrations of NO x demonstrated a relationship with forearm vasodilation estimated by total forearm blood flow following 5 min ischaemia (r = 0.63, P < 0.01) and the flow debt repayment of the forearm (r = 0.54, P < 0.01). Finally, ET-1 concentrations were inversely related to FMD% (r = -0.45, P < 0.05). The findings of the present study demonstrate a relationship between the plasma concentrations of NO x and measures of vascular reactivity in conduit and resistance arteries in patients with CAD. Therefore, measurement of plasma NO x may serve as a reliable marker for peripheral vasodilator dysfunction in patients with CAD.

Original languageEnglish (US)
Pages (from-to)24-28
Number of pages5
JournalClinical and Experimental Pharmacology and Physiology
Volume37
Issue number1
DOIs
StatePublished - Jan 2010

Fingerprint

Vasodilator Agents
Coronary Artery Disease
Forearm
Endothelin-1
Dilatation
Ischemia
Arteries
Plethysmography
Brachial Artery
Hyperemia
Nitrites
Vasodilation
Nitrates
Blood Vessels
Arm

Keywords

  • Coronary artery disease
  • Nitrite/nitrate (NO )
  • Vascular function

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Pharmacology

Cite this

Relationship between endogenous concentrations of vasoactive substances and measures of peripheral vasodilator function in patients with coronary artery disease. / Casey, Darren P.; Nichols, Wilmer W.; Conti, C. Richard; Braith, Randy W.

In: Clinical and Experimental Pharmacology and Physiology, Vol. 37, No. 1, 01.2010, p. 24-28.

Research output: Contribution to journalArticle

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