Relationship between endogenous concentrations of vasoactive substances and measures of peripheral vasodilator function in patients with coronary artery disease

Darren P. Casey, Wilmer W. Nichols, C. Richard Conti, Randy W. Braith

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The aim of the present study was to determine the relationship between plasma concentrations of nitrite/nitrate (NOx) and endothelin (ET)-1 and non-invasive measures of peripheral vasodilator function in patients with coronary artery disease (CAD). Twenty-two patients with angiographic CAD underwent non-invasive measurement of peripheral vasodilator function in the brachial conduit artery (flow-mediated dilation (FMD) testing via ultrasound) and in the forearm resistance arteries (via venous occlusion plethysmography) during reactive hyperaemia after 5 min ischaemia. In addition, plasma NOx and ET-1 concentrations were determined. The plasma concentration of NOx was related to the peak brachial FMD response when expressed as either the relative (%) or absolute (mm) change in diameter (r = 0.73, P < 0.001; and r = 0.64, P < 0.01, respectively). Moreover, plasma concentrations of NOx demonstrated a relationship with forearm vasodilation estimated by total forearm blood flow following 5 min ischaemia (r = 0.63, P < 0.01) and the flow debt repayment of the forearm (r = 0.54, P < 0.01). Finally, ET-1 concentrations were inversely related to FMD% (r = -0.45, P < 0.05). The findings of the present study demonstrate a relationship between the plasma concentrations of NOx and measures of vascular reactivity in conduit and resistance arteries in patients with CAD. Therefore, measurement of plasma NOx may serve as a reliable marker for peripheral vasodilator dysfunction in patients with CAD.

Original languageEnglish (US)
Pages (from-to)24-28
Number of pages5
JournalClinical and Experimental Pharmacology and Physiology
Volume37
Issue number1
DOIs
StatePublished - Jan 1 2010

Keywords

  • Coronary artery disease
  • Nitrite/nitrate (NO)
  • Vascular function

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

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