TY - JOUR
T1 - Relationship between coronary endothelial function and coronary calcification in early atherosclerosis
AU - Han, Seung Hwan
AU - Gerber, Thomas C.
AU - Suwaidi, Jassim Al
AU - Eeckhout, Eric
AU - Lennon, Ryan
AU - Rubinshtein, Ronen
AU - Lerman, Amir
PY - 2010/3/1
Y1 - 2010/3/1
N2 - Background: The relationship between coronary endothelial function and coronary calcification is not well established. Methods: Forty-six patients 17 men [37%]; age, 47.4 ± 11.4 years prospectively underwent testing for coronary endothelial function and measurement of coronary artery calcification (CAC). Results: Log CAC scores were not significantly different between patients with normal (n = 31) and abnormal (n = 15) response of epicardial coronary artery diameter to acetylcholine (%CADAch) (median (25, 75 percentile) 1.1 (0.0, 3.7) vs. 0.3 (0.0, 2.4), P = .32) and with normal (n = 28) and abnormal (n = 18) response of coronary blood flow to acetylcholine (%CBFAch) (0.5 (0.0, 3.6) vs. 0.5 (0.0, 3.2), P = .76). Log CAC scores did not correlate with %CADAch (r = 0.08, P = .59), %CBFAch (r = 0.14, P = .35). Conclusions: In patients without significant coronary artery disease, coronary endothelial dysfunction showed no apparent association with coronary calcification. Our findings suggest that these 2 markers may represent separate, independent processes in the progression of coronary atherosclerosis.
AB - Background: The relationship between coronary endothelial function and coronary calcification is not well established. Methods: Forty-six patients 17 men [37%]; age, 47.4 ± 11.4 years prospectively underwent testing for coronary endothelial function and measurement of coronary artery calcification (CAC). Results: Log CAC scores were not significantly different between patients with normal (n = 31) and abnormal (n = 15) response of epicardial coronary artery diameter to acetylcholine (%CADAch) (median (25, 75 percentile) 1.1 (0.0, 3.7) vs. 0.3 (0.0, 2.4), P = .32) and with normal (n = 28) and abnormal (n = 18) response of coronary blood flow to acetylcholine (%CBFAch) (0.5 (0.0, 3.6) vs. 0.5 (0.0, 3.2), P = .76). Log CAC scores did not correlate with %CADAch (r = 0.08, P = .59), %CBFAch (r = 0.14, P = .35). Conclusions: In patients without significant coronary artery disease, coronary endothelial dysfunction showed no apparent association with coronary calcification. Our findings suggest that these 2 markers may represent separate, independent processes in the progression of coronary atherosclerosis.
KW - Coronary calcification
KW - Early coronary atherosclerosis
KW - Electron beam computed tomography
KW - Endothelial dysfunction
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U2 - 10.1016/j.atherosclerosis.2009.08.027
DO - 10.1016/j.atherosclerosis.2009.08.027
M3 - Article
C2 - 19962702
AN - SCOPUS:77149169099
VL - 209
SP - 197
EP - 200
JO - Atherosclerosis
JF - Atherosclerosis
SN - 0021-9150
IS - 1
ER -