Relationship between breathing and cardiovascular function at rest: Sex-related differences

B. G. Wallin, E. C. Hart, E. A. Wehrwein, N. Charkoudian, Michael Joseph Joyner

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Aim: To compare relationships at rest between breathing rate, levels of muscle sympathetic nerve activity, total peripheral resistance and cardiac output among young men and women. Methods: Recordings were made of respiratory movements, sympathetic nerve activity (peroneal microneurography), intra-arterial blood pressure, electrocardiogram, cardiac output (open-circuit acetylene uptake technique) in 19 healthy men (age 27 ± 2 years, mean ± SEM) and 17 healthy women (age 25 ± 1 years). Total peripheral resistance and stroke volume were calculated. Four minutes epochs of data were analysed. Results: Breathing rates and sympathetic activity were similar in men and women but compared to men, women had significantly lower blood pressures, cardiac output and stroke volume. In men breathing rate correlated positively with sympathetic activity (r = 0.58, P < 0.05) but not in women (r = 0.12, P > 0.05). Furthermore, in men, respiratory rate correlated positively with total peripheral resistance (r = 0.65, P < 0.05) and inversely with cardiac output (r = -0.84, P < 0.05) and heart rate (r = -0.60, P < 0.05) but there were no such relationships in women (P > 0.05 for all). Conclusions: The positive relationship between breathing and sympathetic activity in men, and the inverse coupling of breathing to cardiac output and heart rate suggest that influences of respiration may be important not only for dynamic but also for 'tonic' cardiovascular function. The lack of relationships among these variables in women shows that there are fundamental differences in basic blood pressure regulation between the sexes.

Original languageEnglish (US)
Pages (from-to)193-200
Number of pages8
JournalActa Physiologica
Volume200
Issue number2
DOIs
StatePublished - Oct 2010

Fingerprint

Sex Characteristics
Respiration
Cardiac Output
Vascular Resistance
Stroke Volume
Blood Pressure
Acetylene
Cardiac Volume
Peroneal Nerve
Respiratory Rate
Arterial Pressure
Electrocardiography
Heart Rate
Muscles

Keywords

  • blood pressure
  • gender
  • muscle sympathetic nerve activity
  • respiration

ASJC Scopus subject areas

  • Physiology

Cite this

Relationship between breathing and cardiovascular function at rest : Sex-related differences. / Wallin, B. G.; Hart, E. C.; Wehrwein, E. A.; Charkoudian, N.; Joyner, Michael Joseph.

In: Acta Physiologica, Vol. 200, No. 2, 10.2010, p. 193-200.

Research output: Contribution to journalArticle

Wallin, B. G. ; Hart, E. C. ; Wehrwein, E. A. ; Charkoudian, N. ; Joyner, Michael Joseph. / Relationship between breathing and cardiovascular function at rest : Sex-related differences. In: Acta Physiologica. 2010 ; Vol. 200, No. 2. pp. 193-200.
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