Relationship between body composition and rapidly exchangeable zinc pool in humans

N. G. Egger, K. Yokoi, V. M Sadagopa Ramanujam, H. H. Dayal, N. W. Alcock, H. H. Sandstead

Research output: Contribution to journalArticle

Abstract

The rapidly exchangeable zinc (Zn) pool (EZP) is metabolically important. We measured EZP and plasma Zn turnover rate (TR) of humans (5 males and 11 females, normal plasma Zn) after iv administration of 67Zn. Inductively coupled plasma-mass spectrometry was used for measurement of isotope ratios. EZP was estimated from the 24-h "truncated" exponential kinetic model and the 24-h spot plasma Zn pool. TR was calculated as a product of the plasma Zn (i.e., central) compartment size and the initial slope of the disappearance curve. Lean body weight was measured by the bioelectrical impedance. Skeletal muscle mass was estimated from the 24-h urinary creatinine excretion using Wang et al's formula (AJCN 1996;63:863). EZP obtained from the 24-h kinetic model and the 24-h spot plasma Zn pool are identical (r= 0.994, p<0.0001). Highly significant correlations were found between EZP and body weight (r=0.925, p<0.0001), lean body weight (r=0.861, p<0.0001) and 24-h urinary creatinine excretion or skeletal muscle mass (r=0.900, p<0.0001). In contrast, correlations between EZP and fat mass (r=0.646, p=0.01) were not so high. These results suggest that the skeletal muscle mass is an important contributor for EZP. TR was correlated well with lean body weight (r=0.882, p<0.0001) and EZP (r=0.865, p<0.0001). Because TR (300 - 600 mg/d) is much higher than the excretion rate of Zn (< 10 mg/d), it is closely identical to the Zn uptake rate by tissues. It appears that we observed the same metabolically active mass both initially (TR) and 24 hours later (EZP) through the behavior of the tracer.

Original languageEnglish (US)
JournalFASEB Journal
Volume11
Issue number3
StatePublished - 1997
Externally publishedYes

Fingerprint

Body Composition
body composition
Zinc
zinc
Chemical analysis
Plasmas
skeletal muscle
Body Weight
body weight
excretion
Muscle
Skeletal Muscle
creatinine
Creatinine
kinetics
bioelectrical impedance
Inductively coupled plasma mass spectrometry
atomic absorption spectrometry
Kinetics
Acoustic impedance

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Egger, N. G., Yokoi, K., Ramanujam, V. M. S., Dayal, H. H., Alcock, N. W., & Sandstead, H. H. (1997). Relationship between body composition and rapidly exchangeable zinc pool in humans. FASEB Journal, 11(3).

Relationship between body composition and rapidly exchangeable zinc pool in humans. / Egger, N. G.; Yokoi, K.; Ramanujam, V. M Sadagopa; Dayal, H. H.; Alcock, N. W.; Sandstead, H. H.

In: FASEB Journal, Vol. 11, No. 3, 1997.

Research output: Contribution to journalArticle

Egger, NG, Yokoi, K, Ramanujam, VMS, Dayal, HH, Alcock, NW & Sandstead, HH 1997, 'Relationship between body composition and rapidly exchangeable zinc pool in humans', FASEB Journal, vol. 11, no. 3.
Egger NG, Yokoi K, Ramanujam VMS, Dayal HH, Alcock NW, Sandstead HH. Relationship between body composition and rapidly exchangeable zinc pool in humans. FASEB Journal. 1997;11(3).
Egger, N. G. ; Yokoi, K. ; Ramanujam, V. M Sadagopa ; Dayal, H. H. ; Alcock, N. W. ; Sandstead, H. H. / Relationship between body composition and rapidly exchangeable zinc pool in humans. In: FASEB Journal. 1997 ; Vol. 11, No. 3.
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