Relation of nonperfused myocardial volume and surface area to left ventricular performance in coronary microembolization

Nasser M. Malyar, Lilach O Lerman, Mario Gössl, Patricia E. Beighley, Erik L. Ritman

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background - After occlusion of an epicardial artery, left ventricular (LV) dysfunction is closely related to the volume of nonperfused myocardium (NPM). The impact of coronary microembolization (ME) on LV function, however, is larger relative to the total volume of NPM. We hypothesized that the total surface area (SA), rather than the total volume, of NPM is the major determinant of ME-induced LV dysfunction. Methods and Results - We injected microspheres of 10-, 30-, or 100-μm diameter at each of 3 doses selectively into the left anterior descending coronary artery of 48 anesthetized pigs. Electron beam computed tomography (CT) was used to measure regional myocardial perfusion and changes in LV wall thickening (ΔWT) and stroke volume (ΔSV) after ME. At postmortem, a transmural "biopsy" of 1 to 2 cm3 of embolized myocardium was imaged by micro-CT, resulting in 3D images that provided volumes and SAs of the individual nonperfused foci. Additionally, in 9 pigs, creatine phosphokinase (CK) activity in embolized myocardium was measured as an index of washout of substances from the NPM. After ME, ΔWT, ΔSV, and CK washout were correlated more closely with the total SA (r=0.95, P<0.001; r=0.68, P<0.01; and r=0.88, P=0-01, respectively) than with the total NPM volume (r=0.59, P>0.05; 0.46, P>0.05; and r=0.69, P=0.04, respectively). Conclusion - After coronary ME, LV dysfunction is more closely related to the total SA than to the total volume of nonperfused microregions in the myocardium.

Original languageEnglish (US)
Pages (from-to)1946-1952
Number of pages7
JournalCirculation
Volume110
Issue number14
DOIs
StatePublished - Oct 5 2004

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Myocardium
Left Ventricular Dysfunction
Stroke Volume
Swine
X Ray Computed Tomography
Creatine Kinase
Microspheres
Left Ventricular Function
Coronary Vessels
Arteries
Perfusion
Tomography
Biopsy

Keywords

  • Embolism
  • Infarction
  • Microcirculation
  • Tomography
  • Ventricles

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Relation of nonperfused myocardial volume and surface area to left ventricular performance in coronary microembolization. / Malyar, Nasser M.; Lerman, Lilach O; Gössl, Mario; Beighley, Patricia E.; Ritman, Erik L.

In: Circulation, Vol. 110, No. 14, 05.10.2004, p. 1946-1952.

Research output: Contribution to journalArticle

Malyar, Nasser M. ; Lerman, Lilach O ; Gössl, Mario ; Beighley, Patricia E. ; Ritman, Erik L. / Relation of nonperfused myocardial volume and surface area to left ventricular performance in coronary microembolization. In: Circulation. 2004 ; Vol. 110, No. 14. pp. 1946-1952.
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T1 - Relation of nonperfused myocardial volume and surface area to left ventricular performance in coronary microembolization

AU - Malyar, Nasser M.

AU - Lerman, Lilach O

AU - Gössl, Mario

AU - Beighley, Patricia E.

AU - Ritman, Erik L.

PY - 2004/10/5

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N2 - Background - After occlusion of an epicardial artery, left ventricular (LV) dysfunction is closely related to the volume of nonperfused myocardium (NPM). The impact of coronary microembolization (ME) on LV function, however, is larger relative to the total volume of NPM. We hypothesized that the total surface area (SA), rather than the total volume, of NPM is the major determinant of ME-induced LV dysfunction. Methods and Results - We injected microspheres of 10-, 30-, or 100-μm diameter at each of 3 doses selectively into the left anterior descending coronary artery of 48 anesthetized pigs. Electron beam computed tomography (CT) was used to measure regional myocardial perfusion and changes in LV wall thickening (ΔWT) and stroke volume (ΔSV) after ME. At postmortem, a transmural "biopsy" of 1 to 2 cm3 of embolized myocardium was imaged by micro-CT, resulting in 3D images that provided volumes and SAs of the individual nonperfused foci. Additionally, in 9 pigs, creatine phosphokinase (CK) activity in embolized myocardium was measured as an index of washout of substances from the NPM. After ME, ΔWT, ΔSV, and CK washout were correlated more closely with the total SA (r=0.95, P<0.001; r=0.68, P<0.01; and r=0.88, P=0-01, respectively) than with the total NPM volume (r=0.59, P>0.05; 0.46, P>0.05; and r=0.69, P=0.04, respectively). Conclusion - After coronary ME, LV dysfunction is more closely related to the total SA than to the total volume of nonperfused microregions in the myocardium.

AB - Background - After occlusion of an epicardial artery, left ventricular (LV) dysfunction is closely related to the volume of nonperfused myocardium (NPM). The impact of coronary microembolization (ME) on LV function, however, is larger relative to the total volume of NPM. We hypothesized that the total surface area (SA), rather than the total volume, of NPM is the major determinant of ME-induced LV dysfunction. Methods and Results - We injected microspheres of 10-, 30-, or 100-μm diameter at each of 3 doses selectively into the left anterior descending coronary artery of 48 anesthetized pigs. Electron beam computed tomography (CT) was used to measure regional myocardial perfusion and changes in LV wall thickening (ΔWT) and stroke volume (ΔSV) after ME. At postmortem, a transmural "biopsy" of 1 to 2 cm3 of embolized myocardium was imaged by micro-CT, resulting in 3D images that provided volumes and SAs of the individual nonperfused foci. Additionally, in 9 pigs, creatine phosphokinase (CK) activity in embolized myocardium was measured as an index of washout of substances from the NPM. After ME, ΔWT, ΔSV, and CK washout were correlated more closely with the total SA (r=0.95, P<0.001; r=0.68, P<0.01; and r=0.88, P=0-01, respectively) than with the total NPM volume (r=0.59, P>0.05; 0.46, P>0.05; and r=0.69, P=0.04, respectively). Conclusion - After coronary ME, LV dysfunction is more closely related to the total SA than to the total volume of nonperfused microregions in the myocardium.

KW - Embolism

KW - Infarction

KW - Microcirculation

KW - Tomography

KW - Ventricles

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