Relation of Left Atrial Volume to B-Type Natriuretic Peptide Levels in Patients With Stable Chronic Heart Failure

Justin L. Barclay, Kirsten Kruszewski, Bernie L. Croal, Brian H. Cuthbertson, Jae Kuen Oh, Graham S. Hillis

Research output: Contribution to journalArticle

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Abstract

This study assessed the relation between B-type natriuretic peptide (BNP) and echocardiographic indexes of left ventricular (LV) filling pressure in 53 patients with stable heart failure and without significant valvular dysfunction. Left atrial volume indexed to body surface area (LAVi), an indicator of chronic LV filling pressure, was correlated with BNP (r = 0.692, p <0.001) and was the strongest independent predictor of elevated levels in this cohort. LAVi was also the best predictor of BNP ≥100 pg/ml, with an area under the receiver-operating characteristic curve of 0.85 (95% confidence interval 0.74 to 0.96, p <0.001). Using the optimal cutoff of >31 ml/m2, LAVi had a sensitivity of 92% and a specificity of 65% for BNP ≥100 pg/ml. Patients with LAVi >31 ml/m2 had a median BNP of 122 pg/ml, compared with 21 pg/ml in patients with LAVi ≤31 ml/m2 (p <0.001). These findings suggest that in patients with stable heart failure, BNP levels are related to chronic LV filling pressures. This may help explain the relatively modest correlation between BNP and acute measures of LV filling and the heterogeneity in BNP levels in patients with stable heart failure.

Original languageEnglish (US)
Pages (from-to)98-101
Number of pages4
JournalAmerican Journal of Cardiology
Volume98
Issue number1
DOIs
StatePublished - Jul 1 2006

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Brain Natriuretic Peptide
Heart Failure
Ventricular Pressure
Body Surface Area

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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Relation of Left Atrial Volume to B-Type Natriuretic Peptide Levels in Patients With Stable Chronic Heart Failure. / Barclay, Justin L.; Kruszewski, Kirsten; Croal, Bernie L.; Cuthbertson, Brian H.; Oh, Jae Kuen; Hillis, Graham S.

In: American Journal of Cardiology, Vol. 98, No. 1, 01.07.2006, p. 98-101.

Research output: Contribution to journalArticle

Barclay, Justin L. ; Kruszewski, Kirsten ; Croal, Bernie L. ; Cuthbertson, Brian H. ; Oh, Jae Kuen ; Hillis, Graham S. / Relation of Left Atrial Volume to B-Type Natriuretic Peptide Levels in Patients With Stable Chronic Heart Failure. In: American Journal of Cardiology. 2006 ; Vol. 98, No. 1. pp. 98-101.
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