Relation of chronic obstructive pulmonary disease to atrial and ventricular arrhythmias

Tomas Konecny, Jae Yoon Park, Kiran R. Somers, Dana Konecny, Marek Orban, Filip Soucek, Kenneth O. Parker, Paul D Scanlon, Samuel J Asirvatham, Peter A. Brady, Charanjit S. Rihal

Research output: Contribution to journalArticle

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Abstract

Chronic obstructive pulmonary disease (COPD) is associated with increased cardiovascular morbidity and mortality, yet the exact pathophysiological links remain unclear. Whether the presence and severity of COPD are associated with atrial or ventricular arrhythmias recorded on continuous electrocardiographic monitoring is unknown. We identified consecutive adult patients who underwent clinically indicated pulmonary function testing as well as 24-hour Holter monitoring at the Mayo Clinic, Rochester, from 2000 to 2009. Demographic data and relevant co-morbidities were gathered from the electronic medical record; severity of COPD was classified according to the GOLD classification, and arrhythmias were classified in concordance with the current clinical guidelines. From 7,441 patients who were included (age 64 ± 16 years, 49% woman, 92% Caucasian), COPD was diagnosed in 3,121 (41.9%). Compared with those without COPD, the presence and severity of COPD were associated with increased likelihood of atrial fibrillation/atrial flutter (AF/AFL; 23.3% vs 11.0%, respectively, p <0.0001), nonsustained ventricular tachycardia (NSVT; 13.0% vs 5.9%, respectively, p <0.0001), and sustained ventricular tachycardia (0.9% vs 1.6%, respectively, p <0.0001). COPD remained a significant predictor of AF/AFL and NSVT (p <0.0001 and p <0.0001, respectively) after adjusting for age, gender, tobacco use, obesity, hypertension, coronary artery disease, heart failure, diabetes, anemia, cancer, chronic kidney disease, and rate/rhythm control medications. In conclusion, the independent association between the presence and severity of COPD and arrhythmias (AF/AFL and NSVT) provides further insight into the markedly increased cardiovascular mortality of patients with COPD. Further studies should explore which anti-arrhythmic strategies would best apply to the patients with COPD.

Original languageEnglish (US)
Pages (from-to)272-277
Number of pages6
JournalAmerican Journal of Cardiology
Volume114
Issue number2
DOIs
StatePublished - Jul 15 2014

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Chronic Obstructive Pulmonary Disease
Cardiac Arrhythmias
Ventricular Tachycardia
Morbidity
Ambulatory Electrocardiography
Atrial Flutter
Mortality
Electronic Health Records
Kidney Neoplasms
Anti-Arrhythmia Agents
Tobacco Use
Chronic Renal Insufficiency
Atrial Fibrillation
Anemia
Coronary Artery Disease
Heart Failure
Obesity
Demography
Guidelines
Hypertension

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Konecny, T., Park, J. Y., Somers, K. R., Konecny, D., Orban, M., Soucek, F., ... Rihal, C. S. (2014). Relation of chronic obstructive pulmonary disease to atrial and ventricular arrhythmias. American Journal of Cardiology, 114(2), 272-277. https://doi.org/10.1016/j.amjcard.2014.04.030

Relation of chronic obstructive pulmonary disease to atrial and ventricular arrhythmias. / Konecny, Tomas; Park, Jae Yoon; Somers, Kiran R.; Konecny, Dana; Orban, Marek; Soucek, Filip; Parker, Kenneth O.; Scanlon, Paul D; Asirvatham, Samuel J; Brady, Peter A.; Rihal, Charanjit S.

In: American Journal of Cardiology, Vol. 114, No. 2, 15.07.2014, p. 272-277.

Research output: Contribution to journalArticle

Konecny, T, Park, JY, Somers, KR, Konecny, D, Orban, M, Soucek, F, Parker, KO, Scanlon, PD, Asirvatham, SJ, Brady, PA & Rihal, CS 2014, 'Relation of chronic obstructive pulmonary disease to atrial and ventricular arrhythmias', American Journal of Cardiology, vol. 114, no. 2, pp. 272-277. https://doi.org/10.1016/j.amjcard.2014.04.030
Konecny, Tomas ; Park, Jae Yoon ; Somers, Kiran R. ; Konecny, Dana ; Orban, Marek ; Soucek, Filip ; Parker, Kenneth O. ; Scanlon, Paul D ; Asirvatham, Samuel J ; Brady, Peter A. ; Rihal, Charanjit S. / Relation of chronic obstructive pulmonary disease to atrial and ventricular arrhythmias. In: American Journal of Cardiology. 2014 ; Vol. 114, No. 2. pp. 272-277.
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abstract = "Chronic obstructive pulmonary disease (COPD) is associated with increased cardiovascular morbidity and mortality, yet the exact pathophysiological links remain unclear. Whether the presence and severity of COPD are associated with atrial or ventricular arrhythmias recorded on continuous electrocardiographic monitoring is unknown. We identified consecutive adult patients who underwent clinically indicated pulmonary function testing as well as 24-hour Holter monitoring at the Mayo Clinic, Rochester, from 2000 to 2009. Demographic data and relevant co-morbidities were gathered from the electronic medical record; severity of COPD was classified according to the GOLD classification, and arrhythmias were classified in concordance with the current clinical guidelines. From 7,441 patients who were included (age 64 ± 16 years, 49{\%} woman, 92{\%} Caucasian), COPD was diagnosed in 3,121 (41.9{\%}). Compared with those without COPD, the presence and severity of COPD were associated with increased likelihood of atrial fibrillation/atrial flutter (AF/AFL; 23.3{\%} vs 11.0{\%}, respectively, p <0.0001), nonsustained ventricular tachycardia (NSVT; 13.0{\%} vs 5.9{\%}, respectively, p <0.0001), and sustained ventricular tachycardia (0.9{\%} vs 1.6{\%}, respectively, p <0.0001). COPD remained a significant predictor of AF/AFL and NSVT (p <0.0001 and p <0.0001, respectively) after adjusting for age, gender, tobacco use, obesity, hypertension, coronary artery disease, heart failure, diabetes, anemia, cancer, chronic kidney disease, and rate/rhythm control medications. In conclusion, the independent association between the presence and severity of COPD and arrhythmias (AF/AFL and NSVT) provides further insight into the markedly increased cardiovascular mortality of patients with COPD. Further studies should explore which anti-arrhythmic strategies would best apply to the patients with COPD.",
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