Relation of Cardiac Troponin I Measurements at 24 and 48 Hours to Magnetic Resonance-Determined Infarct Size in Patients With ST-Elevation Myocardial Infarction

Jonas Hallén, Peter Buser, Jürg Schwitter, Peter Petzelbauer, Bernard Geudelin, Morten W. Fagerland, Allan S Jaffe, Dan Atar

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Levels of circulating cardiac troponin I (cTnI) or T are correlated to extent of myocardial destruction after an acute myocardial infarction. Few studies analyzing this relation have employed a second-generation cTnI assay or cardiac magnetic resonance (CMR) as the imaging end point. In this post hoc study of the Efficacy of FX06 in the Prevention of Mycoardial Reperfusion Injury (F.I.R.E.) trial, we aimed at determining the correlation between single-point cTnI measurements and CMR-estimated infarct size at 5 to 7 days and 4 months after a first-time ST-elevation myocardial infarction (STEMI) and investigating whether cTnI might provide independent prognostic information regarding infarct size at 4 months even taking into account early infarct size. Two hundred twenty-seven patients with a first-time STEMI were included in F.I.R.E. All patients received primary percutaneous coronary intervention within 6 hours from onset of symptoms. cTnI was measured at 24 and 48 hours after admission. CMR was conducted within 1 week of the index event (5 to 7 days) and at 4 months. Pearson correlations (r) for infarct size and cTnI at 24 hours were r = 0.66 (5 days) and r = 0.63 (4 months) and those for cTnI at 48 hours were r = 0.67 (5 days) and r = 0.65 (4 months). In a multiple regression analysis for predicting infarct size at 4 months (n = 141), cTnI and infarct location retained an independent prognostic role even taking into account early infarct size. In conclusion, a single-point cTnI measurement taken early after a first-time STEMI is a useful marker for infarct size and might also supplement early CMR evaluation in prediction of infarct size at 4 months.

Original languageEnglish (US)
Pages (from-to)1472-1477
Number of pages6
JournalAmerican Journal of Cardiology
Volume104
Issue number11
DOIs
StatePublished - Dec 1 2009
Externally publishedYes

Fingerprint

Troponin I
Magnetic Resonance Spectroscopy
ST Elevation Myocardial Infarction
Troponin T
Percutaneous Coronary Intervention
Reperfusion Injury
Myocardial Infarction
Regression Analysis
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Relation of Cardiac Troponin I Measurements at 24 and 48 Hours to Magnetic Resonance-Determined Infarct Size in Patients With ST-Elevation Myocardial Infarction. / Hallén, Jonas; Buser, Peter; Schwitter, Jürg; Petzelbauer, Peter; Geudelin, Bernard; Fagerland, Morten W.; Jaffe, Allan S; Atar, Dan.

In: American Journal of Cardiology, Vol. 104, No. 11, 01.12.2009, p. 1472-1477.

Research output: Contribution to journalArticle

Hallén, Jonas ; Buser, Peter ; Schwitter, Jürg ; Petzelbauer, Peter ; Geudelin, Bernard ; Fagerland, Morten W. ; Jaffe, Allan S ; Atar, Dan. / Relation of Cardiac Troponin I Measurements at 24 and 48 Hours to Magnetic Resonance-Determined Infarct Size in Patients With ST-Elevation Myocardial Infarction. In: American Journal of Cardiology. 2009 ; Vol. 104, No. 11. pp. 1472-1477.
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AU - Schwitter, Jürg

AU - Petzelbauer, Peter

AU - Geudelin, Bernard

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AU - Jaffe, Allan S

AU - Atar, Dan

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