Relation between vitamin D status and nonalcoholic fatty liver disease in children

Suchitra K. Hourigan, Stephanie Abrams, Katherine Yates, Kim Pfeifer, Michael Torbenson, Karen Murray, Christian L. Roth, Kris Kowdley, Ann O. Scheimann

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Objectives: In adults, vitamin D deficiency is common in patients with nonalcoholic fatty liver disease (NAFLD) and has been associated with the severity of histology. There are known differences between adult and pediatric NAFLD, with little data regarding the relation between vitamin D and pediatric NAFLD. The aim of the present study was to examine the relation between vitamin D levels and NAFLD in children. Methods: Clinical and histological data were used from children ages 2 to 18 years with biopsy-proven NAFLD enrolled in the Nonalcoholic Steatohepatitis Clinical Research Network studies. 25(OH) vitamin D levels were measured from serum. Data examined included demographics, anthropometrics, laboratory markers, and liver histology. Data were analyzed using 3 categories of vitamin D level: deficient (≤20 ng/ mL), insufficient (21-29 ng/mL), and sufficient (≥30 ng/mL). Results: A total of 102 children were studied. There was a high prevalence (80/102, 78%) of vitamin D deficiency or insufficiency; however, there were no significant associations between vitamin D level and the histological characteristics or severity of NAFLD. Significantly higher levels of triglycerides were found in those with vitamin D deficiency (P=0.004), but there was no association with other features of the metabolic syndrome. Conclusions: There is a high prevalence of vitamin D deficiency and insufficiency in children with biopsy-proven NAFLD; however, no association was found between vitamin D deficiency and the severity of disease on biopsies. This differs from adult NAFLD studies in which vitamin D deficiency correlates with histological severity, suggesting differences in the risk factors for or consequences of pediatric NAFLD.

Original languageEnglish (US)
Pages (from-to)396-404
Number of pages9
JournalJournal of pediatric gastroenterology and nutrition
Volume60
Issue number3
DOIs
StatePublished - Mar 7 2015

Keywords

  • children
  • nonalcoholic fatty liver disease
  • pediatrics
  • vitamin D

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Gastroenterology

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    Hourigan, S. K., Abrams, S., Yates, K., Pfeifer, K., Torbenson, M., Murray, K., Roth, C. L., Kowdley, K., & Scheimann, A. O. (2015). Relation between vitamin D status and nonalcoholic fatty liver disease in children. Journal of pediatric gastroenterology and nutrition, 60(3), 396-404. https://doi.org/10.1097/MPG.0000000000000598