Relapse of inflammatory bowel disease associated with use of nonsteroidal anti-inflammatory drugs

Angela M. Meyer, Nizar N. Ramzan, Russell I. Heigh, Jonathan A Leighton

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

To determine whether an association exists between relapse in inflammatory bowel disease and use of nonsteroidal anti-inflammatory drugs (NSAIDs), a retrospective records review was conducted of patients with Crohn's disease, ulcerative colitis, or indeterminate colitis examined at an outpatient tertiary care center between July 17, 2000, and November 1, 2001. Extracted data collected during the patient's last visit included medication use, maintenance therapy, disease activity, and smoking status. Use of NSAIDs was defined as a daily dose or more of any type the month before relapse. Of 60 patients (22, relapse; 38, remission), 9 (41%) in relapse and 10 (26%) in remission used NSAIDs. Maintenance therapy varied from 68% (relapse) to 92% (remission). The adjusted odds ratio between medication use and relapse was 6.31 (95% confidence interval, 1.16-34.38; P = .03). Use of NSAIDs was associated with relapse. A prospective cohort study that corrects for maintenance therapy is needed to evaluate this relationship.

Original languageEnglish (US)
Pages (from-to)168-172
Number of pages5
JournalDigestive Diseases and Sciences
Volume51
Issue number1
DOIs
StatePublished - Jan 2006

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Inflammatory Bowel Diseases
Anti-Inflammatory Agents
Recurrence
Pharmaceutical Preparations
Colitis
Ambulatory Care
Ulcerative Colitis
Tertiary Care Centers
Crohn Disease
Cohort Studies
Therapeutics
Smoking
Odds Ratio
Prospective Studies
Confidence Intervals

Keywords

  • Colitis
  • Crohn's disease
  • Inflammatory bowel disease
  • Nonsteroidal anti-inflammatory drugs
  • Ulcerative

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Relapse of inflammatory bowel disease associated with use of nonsteroidal anti-inflammatory drugs. / Meyer, Angela M.; Ramzan, Nizar N.; Heigh, Russell I.; Leighton, Jonathan A.

In: Digestive Diseases and Sciences, Vol. 51, No. 1, 01.2006, p. 168-172.

Research output: Contribution to journalArticle

Meyer, Angela M. ; Ramzan, Nizar N. ; Heigh, Russell I. ; Leighton, Jonathan A. / Relapse of inflammatory bowel disease associated with use of nonsteroidal anti-inflammatory drugs. In: Digestive Diseases and Sciences. 2006 ; Vol. 51, No. 1. pp. 168-172.
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