Regulation of tyrosine hydroxylase activity in mouse neuroblastoma clone N1E 115

E. Richelson

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

Mouse neuroblastoma (clone NIE 115) cells in the logarithmic growth phase were incubated for 12 days. From early log phase to late stationary phase, the specific activity of tyrosine hydroxylase (EC 1.14.3a) increased by more than 30 fold. The increase in tyrosine hydroxylase per cell and per dish was 12 and 2700 fold, respectively. When cell division was stopped by removing serum or by adding 0.1 mM 5 fluorodeoxyuridine and 0.1 mM uridine, the enzyme activity was also found to increase. These results show that tyrosine hydroxylase is regulated in neuroblastoma clone N1E 115.

Original languageEnglish (US)
Pages (from-to)1139-1145
Number of pages7
JournalJournal of Neurochemistry
Volume21
Issue number5
StatePublished - 1973
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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