Regulation of the T-independent humoral response by TACI

Götz Ulrich Von Bülow, Jan M. Van Deursen, Richard J. Bram

Research output: Contribution to journalArticlepeer-review

400 Scopus citations

Abstract

TACI is a TNFR homolog expressed by mature B lymphocytes that has been implicated in the positive regulation of B cell growth and antibody production, as well as in the development of autoimmune disease. Its biology is complex due to the existence of two ligands, BLyS and APRIL, and a homologous receptor, BCMA, that similarly binds both ligands. To determine its critical biological role, we generated TACI knockout mice. Surprisingly, these mice demonstrated a 2-fold increase in numbers of circulating and splenic B cells, apparently due to increased proliferation rate. Maturation of B cells and T-dependent antibody production was normal, but responses to T-independent type II antigens were almost completely abolished. It appears that TACI provides an essential costimulatory signal for the T-independent humoral response.

Original languageEnglish (US)
Article number129
Pages (from-to)573-582
Number of pages10
JournalImmunity
Volume14
Issue number5
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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