Abstract
The contractile phenotype of a smooth muscle can broadly be classified as phasic or tonic. Following activation, phasic smooth muscle exhibits an initial period of rapid force activation, following which force falls to a lower steady state level. In contrast, force generated by tonic smooth muscle rises slowly to a sustained steady state. The differences in contractile patterns cannot be explained by the time course of either the Ca2+ transient or phosphorylation of the 20-kDa regulatory myosin light chain (MLC20). Therefore, a molecular marker that defines tonic and phasic smooth muscle contractile properties remains elusive. Further, smooth muscle can maintain force at low levels of MLC20 phosphorylation; often referred to as the latch state. The mechanism for the latch state is unknown and has been hypothesized to be due to a number of mechanisms including the formation of slowly cycling dephosphorylated or latch cross-bridges (Hai and Murphy, Am J Physiol 253:H1365-H1371, 1988). This review will focus evidence suggesting that nonmuscle myosin IIB (NMIIB) are the latch cross-bridges in smooth muscle and NMIIB content could define the tonic contractile phenotype.
Original language | English (US) |
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Pages (from-to) | 409-414 |
Number of pages | 6 |
Journal | Journal of Muscle Research and Cell Motility |
Volume | 28 |
Issue number | 7-8 |
DOIs | |
State | Published - Oct 2007 |
Keywords
- Contractility
- Cross-bridge
- Force maintenance
- Latch state
ASJC Scopus subject areas
- Biochemistry
- Physiology
- Cell Biology