Regulation of sex hormone receptors in sexual dimorphism of human cancers

Daoshan Zheng; Cecilia Williams; Jeremy A. Vold; Justin H. Nguyen; Denise M. Harnois; Sanjay P. Bagaria; Sarah A. McLaughlin; Zhaoyu Li

doi:10.1016/j.canlet.2018.09.001

Regulation of sex hormone receptors in sexual dimorphism of human cancers

Daoshan Zheng, Cecilia Williams, Jeremy A. Vold, Justin H. Nguyen, Denise M. Harnois, Sanjay P. Bagaria, Sarah A. McLaughlin, Zhaoyu Li

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Gender differences in the incidences of cancers have been found in almost all human cancers. However, the mechanisms that underlie gender disparities in most human cancer types have been under-investigated. Here, we provide a comprehensive overview of potential mechanisms underlying sexual dimorphism of each cancer regarding sex hormone signaling. Fully addressing the mechanisms of sexual dimorphism in human cancers will greatly benefit current development of precision medicine. Our discussions of potential mechanisms underlying sexual dimorphism in each cancer will be instructive for future cancer research on gender disparities.

Original language	English (US)
Pages (from-to)	24-31
Number of pages	8
Journal	Cancer Letters
Volume	438
DOIs	https://doi.org/10.1016/j.canlet.2018.09.001
State	Published - Dec 1 2018

Keywords

Androgen receptor
Cancer incidence
Estrogen receptor
Sex hormones
Sexual dimorphism

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.canlet.2018.09.001

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title = "Regulation of sex hormone receptors in sexual dimorphism of human cancers",

abstract = "Gender differences in the incidences of cancers have been found in almost all human cancers. However, the mechanisms that underlie gender disparities in most human cancer types have been under-investigated. Here, we provide a comprehensive overview of potential mechanisms underlying sexual dimorphism of each cancer regarding sex hormone signaling. Fully addressing the mechanisms of sexual dimorphism in human cancers will greatly benefit current development of precision medicine. Our discussions of potential mechanisms underlying sexual dimorphism in each cancer will be instructive for future cancer research on gender disparities.",

keywords = "Androgen receptor, Cancer incidence, Estrogen receptor, Sex hormones, Sexual dimorphism",

author = "Daoshan Zheng and Cecilia Williams and Vold, {Jeremy A.} and Nguyen, {Justin H.} and Harnois, {Denise M.} and Bagaria, {Sanjay P.} and McLaughlin, {Sarah A.} and Zhaoyu Li",

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year = "2018",

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doi = "10.1016/j.canlet.2018.09.001",

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T1 - Regulation of sex hormone receptors in sexual dimorphism of human cancers

AU - Zheng, Daoshan

AU - Williams, Cecilia

AU - Vold, Jeremy A.

AU - Nguyen, Justin H.

AU - Harnois, Denise M.

AU - Bagaria, Sanjay P.

AU - McLaughlin, Sarah A.

AU - Li, Zhaoyu

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Gender differences in the incidences of cancers have been found in almost all human cancers. However, the mechanisms that underlie gender disparities in most human cancer types have been under-investigated. Here, we provide a comprehensive overview of potential mechanisms underlying sexual dimorphism of each cancer regarding sex hormone signaling. Fully addressing the mechanisms of sexual dimorphism in human cancers will greatly benefit current development of precision medicine. Our discussions of potential mechanisms underlying sexual dimorphism in each cancer will be instructive for future cancer research on gender disparities.

AB - Gender differences in the incidences of cancers have been found in almost all human cancers. However, the mechanisms that underlie gender disparities in most human cancer types have been under-investigated. Here, we provide a comprehensive overview of potential mechanisms underlying sexual dimorphism of each cancer regarding sex hormone signaling. Fully addressing the mechanisms of sexual dimorphism in human cancers will greatly benefit current development of precision medicine. Our discussions of potential mechanisms underlying sexual dimorphism in each cancer will be instructive for future cancer research on gender disparities.

KW - Androgen receptor

KW - Cancer incidence

KW - Estrogen receptor

KW - Sex hormones

KW - Sexual dimorphism

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DO - 10.1016/j.canlet.2018.09.001

M3 - Review article

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AN - SCOPUS:85053435783

SN - 0304-3835

VL - 438

SP - 24

EP - 31

JO - Cancer Letters

JF - Cancer Letters

ER -

Regulation of sex hormone receptors in sexual dimorphism of human cancers

Abstract

Keywords

ASJC Scopus subject areas

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