Regulation of sex hormone receptors in sexual dimorphism of human cancers

Daoshan Zheng, Cecilia Williams, Jeremy A. Vold, Justin H. Nguyen, Denise M. Harnois, Sanjay P Bagaria, Sarah A McLaughlin, Zhaoyu Li

Research output: Contribution to journalShort survey

1 Scopus citations

Abstract

Gender differences in the incidences of cancers have been found in almost all human cancers. However, the mechanisms that underlie gender disparities in most human cancer types have been under-investigated. Here, we provide a comprehensive overview of potential mechanisms underlying sexual dimorphism of each cancer regarding sex hormone signaling. Fully addressing the mechanisms of sexual dimorphism in human cancers will greatly benefit current development of precision medicine. Our discussions of potential mechanisms underlying sexual dimorphism in each cancer will be instructive for future cancer research on gender disparities.

Original languageEnglish (US)
Pages (from-to)24-31
Number of pages8
JournalCancer Letters
Volume438
DOIs
StatePublished - Dec 1 2018

Keywords

  • Androgen receptor
  • Cancer incidence
  • Estrogen receptor
  • Sex hormones
  • Sexual dimorphism

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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