Regulation of phosphate homeostasis by the phosphatonins and other novel mediators

Aisha Shaikh, Theresa Berndt, Rajiv Kumar

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

A variety of factors regulate the efficiency of phosphate absorption in the intestine and phosphate reabsorption in kidney. Apart from the well-known regulators of phosphate homeostasis, namely parathyroid hormone (PTH) and the vitamin D-endocrine system, a number of peptides collectively known as the "phosphatonins" have been recently identified as a result of the study of various diseases associated with hypophosphatemia. These factors, fibroblast growth factor 23 (FGF-23), secreted frizzled-related protein 4 (sFRP-4), fibroblast growth factor 7 (FGF-7) and matrix extracellular phosphoglycoprotein (MEPE), have been shown to play a role in the pathogenesis of various hypophosphatemic and hyperphosphatemic disorders, such as oncogenic osteomalacia, X-linked hypophosphatemic rickets, autosomal dominant hypophosphatemic rickets, autosomal recessive hypophosphatemia and tumoral calcinosis. Whether these factors are true hormones, in the sense that they are regulated by the intake of dietary phosphorus and the needs of the organism for higher or lower amounts of phosphorus, remains to be firmly established in humans. Additionally, new information demonstrates that the intestine "senses" luminal concentrations of phosphate and regulates the excretion of phosphate in the kidney by elaborating novel factors that alter renal phosphate reabsorption.

Original languageEnglish (US)
Pages (from-to)1203-1210
Number of pages8
JournalPediatric Nephrology
Volume23
Issue number8
DOIs
StatePublished - Aug 2008

Fingerprint

Homeostasis
Phosphates
Intestines
Dietary Phosphorus
Familial Hypophosphatemic Rickets
Fibroblast Growth Factor 7
Hypophosphatemia
Kidney
Calcinosis
Endocrine System
Parathyroid Hormone
Vitamin D
Phosphorus
Extracellular Matrix
Hormones
Peptides

Keywords

  • Fibroblast growth factors
  • Phosphate
  • Phosphatonins
  • PTH
  • Vitamin D

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health

Cite this

Regulation of phosphate homeostasis by the phosphatonins and other novel mediators. / Shaikh, Aisha; Berndt, Theresa; Kumar, Rajiv.

In: Pediatric Nephrology, Vol. 23, No. 8, 08.2008, p. 1203-1210.

Research output: Contribution to journalArticle

Shaikh, Aisha ; Berndt, Theresa ; Kumar, Rajiv. / Regulation of phosphate homeostasis by the phosphatonins and other novel mediators. In: Pediatric Nephrology. 2008 ; Vol. 23, No. 8. pp. 1203-1210.
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