Regulation of NK cell-mediated cytotoxicity by the adaptor protein 3BP2

D. Jevremovic, D. D. Billadeau, R. A. Schoon, C. J. Dick, P. J. Leibson

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

Stimulation of lymphocytes through multichain immune recognition receptors activates multiple signaling pathways. Adaptor proteins play an important role in integrating these pathways by their ability to simultaneously bind multiple signaling components. Recently, the 3BP2 adaptor protein has been shown to positively regulate the transcriptional activity of T cells. However, the mechanisms by which signaling components are involved in this regulation remain unclear, as does a potential role for 3BP2 in the regulation of other cellular functions. Here we describe a positive regulatory role for 3BP2 in NK cell-mediated cytotoxicity. We also identify p95vav and phospholipase C-γ isoforms as binding partners of 3BP2. Our results show that tyrosine-183 of 3BP2 is specifically involved in this interaction and that this residue critically influences 3BP2-dependent function. Therefore, 3BP2 regulates NK cell-mediated cytotoxicity by mobilizing key downstream signaling effectors.

Original languageEnglish (US)
Pages (from-to)7219-7228
Number of pages10
JournalJournal of Immunology
Volume166
Issue number12
DOIs
StatePublished - Jun 15 2001

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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