Regulation of neurotensin receptor mRNA expression by the receptor antagonist SR 48692 in the rat midbrain dopaminergic neurons

Mitsuhiko Yamada; Carolyn Bolden-Watson; Michael A. Watson; Toshihiro Cho; Nailah J. Coleman; Misa Yamada; Elliott Richelson

doi:10.1016/0169-328X(95)00094-9

Regulation of neurotensin receptor mRNA expression by the receptor antagonist SR 48692 in the rat midbrain dopaminergic neurons

Mitsuhiko Yamada, Carolyn Bolden-Watson, Michael A. Watson, Toshihiro Cho, Nailah J. Coleman, Misa Yamada, Elliott Richelson

Neuroscience

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

In this study, we demonstrated that the tyrosine hydroxylase-like immuno-reactive (possibly dopaminergic) neurons express neurotensin receptor mRNA in the rat substantia nigra and in the ventral tegmental area. Additionally, 2 weeks treatment with the neurotensin receptor antagonist SR 48692 increased mRNA levels in the substantia nigra. These data suggest that neurotensin receptor expression in the perikarya and in the terminal regions of dopaminergic neurons is regulated by its endogenous agonist in vivo.

Original language	English (US)
Pages (from-to)	343-346
Number of pages	4
Journal	Molecular Brain Research
Volume	33
Issue number	2
DOIs	https://doi.org/10.1016/0169-328X(95)00094-9
State	Published - Nov 1995

Keywords

Antagonist
Dopamine
Messenger RNA
Neurotensin receptor
SR 48692
Up-regulation

ASJC Scopus subject areas

Molecular Biology
Cellular and Molecular Neuroscience

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10.1016/0169-328X(95)00094-9

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title = "Regulation of neurotensin receptor mRNA expression by the receptor antagonist SR 48692 in the rat midbrain dopaminergic neurons",

abstract = "In this study, we demonstrated that the tyrosine hydroxylase-like immuno-reactive (possibly dopaminergic) neurons express neurotensin receptor mRNA in the rat substantia nigra and in the ventral tegmental area. Additionally, 2 weeks treatment with the neurotensin receptor antagonist SR 48692 increased mRNA levels in the substantia nigra. These data suggest that neurotensin receptor expression in the perikarya and in the terminal regions of dopaminergic neurons is regulated by its endogenous agonist in vivo.",

keywords = "Antagonist, Dopamine, Messenger RNA, Neurotensin receptor, SR 48692, Up-regulation",

author = "Mitsuhiko Yamada and Carolyn Bolden-Watson and Watson, {Michael A.} and Toshihiro Cho and Coleman, {Nailah J.} and Misa Yamada and Elliott Richelson",

note = "Funding Information: The authors thank Dr. S. Shioda from the Department of Anatomy, Showa University School of Medicine for helpful discussions. This work was supported by The American Parkinson Disease Association, Inc., Mayo Foundation, and Grant MH27692 from the USPHS (N!MH).",

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T1 - Regulation of neurotensin receptor mRNA expression by the receptor antagonist SR 48692 in the rat midbrain dopaminergic neurons

AU - Yamada, Mitsuhiko

AU - Bolden-Watson, Carolyn

AU - Watson, Michael A.

AU - Cho, Toshihiro

AU - Coleman, Nailah J.

AU - Yamada, Misa

AU - Richelson, Elliott

N1 - Funding Information: The authors thank Dr. S. Shioda from the Department of Anatomy, Showa University School of Medicine for helpful discussions. This work was supported by The American Parkinson Disease Association, Inc., Mayo Foundation, and Grant MH27692 from the USPHS (N!MH).

PY - 1995/11

Y1 - 1995/11

N2 - In this study, we demonstrated that the tyrosine hydroxylase-like immuno-reactive (possibly dopaminergic) neurons express neurotensin receptor mRNA in the rat substantia nigra and in the ventral tegmental area. Additionally, 2 weeks treatment with the neurotensin receptor antagonist SR 48692 increased mRNA levels in the substantia nigra. These data suggest that neurotensin receptor expression in the perikarya and in the terminal regions of dopaminergic neurons is regulated by its endogenous agonist in vivo.

AB - In this study, we demonstrated that the tyrosine hydroxylase-like immuno-reactive (possibly dopaminergic) neurons express neurotensin receptor mRNA in the rat substantia nigra and in the ventral tegmental area. Additionally, 2 weeks treatment with the neurotensin receptor antagonist SR 48692 increased mRNA levels in the substantia nigra. These data suggest that neurotensin receptor expression in the perikarya and in the terminal regions of dopaminergic neurons is regulated by its endogenous agonist in vivo.

KW - Antagonist

KW - Dopamine

KW - Messenger RNA

KW - Neurotensin receptor

KW - SR 48692

KW - Up-regulation

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Regulation of neurotensin receptor mRNA expression by the receptor antagonist SR 48692 in the rat midbrain dopaminergic neurons

Abstract

Keywords

ASJC Scopus subject areas

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