Regulation of neurotensin receptor mRNA expression by the receptor antagonist SR 48692 in the rat midbrain dopaminergic neurons

Mitsuhiko Yamada, Carolyn Bolden-Watson, Michael A. Watson, Toshihiro Cho, Nailah J. Coleman, Misa Yamada, Elliott Richelson

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

In this study, we demonstrated that the tyrosine hydroxylase-like immuno-reactive (possibly dopaminergic) neurons express neurotensin receptor mRNA in the rat substantia nigra and in the ventral tegmental area. Additionally, 2 weeks treatment with the neurotensin receptor antagonist SR 48692 increased mRNA levels in the substantia nigra. These data suggest that neurotensin receptor expression in the perikarya and in the terminal regions of dopaminergic neurons is regulated by its endogenous agonist in vivo.

Original languageEnglish (US)
Pages (from-to)343-346
Number of pages4
JournalMolecular Brain Research
Volume33
Issue number2
DOIs
StatePublished - 1995

Keywords

  • Antagonist
  • Dopamine
  • Messenger RNA
  • Neurotensin receptor
  • SR 48692
  • Up-regulation

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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