Regulation of mucin genes in chronic inflammatory airway diseases

Judith A. Voynow, Sandra J. Gendler, Mary C. Rose

Research output: Contribution to journalReview article

149 Scopus citations

Abstract

In this review, we summarize work over the past 15 years on mucin gene expression and regulation in the lung, as well as how mucin gene expression is altered in chronic lung diseases. This field owes a great debt to Carol Basbaum for her pioneering work in dissecting signaling pathways regulating mucin gene expression and for her tremendous energy in promoting the importance of understanding the basic pathogenic mechanisms that drive mucus overproduction in cystic fibrosis, chronic obstructive pulmonary disease, and asthma.

Original languageEnglish (US)
Pages (from-to)661-665
Number of pages5
JournalAmerican journal of respiratory cell and molecular biology
Volume34
Issue number6
DOIs
StatePublished - Jun 1 2006

ASJC Scopus subject areas

  • Molecular Biology
  • Pulmonary and Respiratory Medicine
  • Clinical Biochemistry
  • Cell Biology

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