Abstract
Differentiation of specialized cell types from stem and progenitor cells is tightly regulated at several levels, both during development and during somatic tissue homeostasis. Many long non-coding RNAs have been recognized as an additional layer of regulation in the specification of cellular identities; these non-coding species can modulate gene-expression programmes in various biological contexts through diverse mechanisms at the transcriptional, translational or messenger RNA stability levels. Here, we summarize findings that implicate long non-coding RNAs in the control of mammalian cell differentiation. We focus on several representative differentiation systems and discuss how specific long non-coding RNAs contribute to the regulation of mammalian development.
Original language | English (US) |
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Pages (from-to) | 971-983 |
Number of pages | 13 |
Journal | EMBO Reports |
Volume | 13 |
Issue number | 11 |
DOIs | |
State | Published - Nov 2012 |
Keywords
- cell differentiation
- lncRNA
- pluripotency
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Genetics