Regulation of mammalian cell differentiation by long non-coding RNAs

Wengian Hu, Juan R. Alvarez-Dominguez, Harvey F. Lodish

Research output: Contribution to journalReview article

200 Citations (Scopus)

Abstract

Differentiation of specialized cell types from stem and progenitor cells is tightly regulated at several levels, both during development and during somatic tissue homeostasis. Many long non-coding RNAs have been recognized as an additional layer of regulation in the specification of cellular identities; these non-coding species can modulate gene-expression programmes in various biological contexts through diverse mechanisms at the transcriptional, translational or messenger RNA stability levels. Here, we summarize findings that implicate long non-coding RNAs in the control of mammalian cell differentiation. We focus on several representative differentiation systems and discuss how specific long non-coding RNAs contribute to the regulation of mammalian development.

Original languageEnglish (US)
Pages (from-to)971-983
Number of pages13
JournalEMBO Reports
Volume13
Issue number11
DOIs
StatePublished - Nov 2012
Externally publishedYes

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Long Noncoding RNA
Cell Differentiation
Cells
Tissue homeostasis
Stem Cells
RNA Stability
Gene expression
Homeostasis
Specifications
Gene Expression
Messenger RNA

Keywords

  • cell differentiation
  • lncRNA
  • pluripotency

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Biochemistry

Cite this

Regulation of mammalian cell differentiation by long non-coding RNAs. / Hu, Wengian; Alvarez-Dominguez, Juan R.; Lodish, Harvey F.

In: EMBO Reports, Vol. 13, No. 11, 11.2012, p. 971-983.

Research output: Contribution to journalReview article

Hu, Wengian ; Alvarez-Dominguez, Juan R. ; Lodish, Harvey F. / Regulation of mammalian cell differentiation by long non-coding RNAs. In: EMBO Reports. 2012 ; Vol. 13, No. 11. pp. 971-983.
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