Regulation of human dihydropyrimidime dehydrogenase: Implications in the pharmacogenetics of 5-FU-based chemotheraphy

Xue Zhang, Robert B. Diasio

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

Dihydropyrimidine dehydrogenase is the enzyme that is critical for the efficacy and toxicity of the anticancer reagent 5-fluorouracil. It has been demonstrated that the regulation of the dihydropyrimidine dehydrogenase gene has an important role in the determination of the enzyme activity of dihydropyrimidine dehydrogenase. The regulation of the gene expression is thus discussed from two aspects: normal regulation by specificity proteins, and the epigenetic regulation by promoter methylation. The influence of the polymorphism on dihydropyrimidine dehydrogenase enzyme activity and other factors that have been suo0ested to be involved in dihydropyrimidine dehydrogenase regulation are also discussed.

Original languageEnglish (US)
Pages (from-to)257-265
Number of pages9
JournalPharmacogenomics
Volume8
Issue number3
DOIs
StatePublished - Mar 1 2007

Keywords

  • Dihydropyrimidine dehydrogenase
  • Dihydropyrimidine dehydrogenase gene
  • Gene regulation
  • Promoter methylation

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmacology

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