Regulation of human B lymphocyte responsiveness.

P. E. Lipsky, S. Hirohata, Diane F Jelinek, L. McAnally, J. B. Splawski

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Regulation of human B cell responses is a complex process involving the activities of a variety of cells and cytokines. There are important differences between the regulation of human and murine B lymphocytes, especially with regard to the action of IL2 and IL4. In man, IL2 appears to play a central role in regulating B cell activation, proliferation and differentiation, whereas IL4 plays a regulatory role by inhibiting initial B cell activation. Above and beyond providing regulatory cytokines, activated human T cells can also directly stimulate B cell differentiation by a process that requires cellular contact. A better understanding of the nature of signal transduction during interactions between B cells and activated T cells and provided by the various cytokines should provide additional insight into the regulation of B cell function in man.

Original languageEnglish (US)
Pages (from-to)229-235
Number of pages7
JournalScandinavian Journal of Rheumatology, Supplement
Volume76
StatePublished - 1988
Externally publishedYes

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B-Lymphocytes
Cytokines
Interleukin-4
Interleukin-2
Cell Differentiation
T-Lymphocytes
Signal Transduction
Cell Proliferation

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Lipsky, P. E., Hirohata, S., Jelinek, D. F., McAnally, L., & Splawski, J. B. (1988). Regulation of human B lymphocyte responsiveness. Scandinavian Journal of Rheumatology, Supplement, 76, 229-235.

Regulation of human B lymphocyte responsiveness. / Lipsky, P. E.; Hirohata, S.; Jelinek, Diane F; McAnally, L.; Splawski, J. B.

In: Scandinavian Journal of Rheumatology, Supplement, Vol. 76, 1988, p. 229-235.

Research output: Contribution to journalArticle

Lipsky, PE, Hirohata, S, Jelinek, DF, McAnally, L & Splawski, JB 1988, 'Regulation of human B lymphocyte responsiveness.', Scandinavian Journal of Rheumatology, Supplement, vol. 76, pp. 229-235.
Lipsky, P. E. ; Hirohata, S. ; Jelinek, Diane F ; McAnally, L. ; Splawski, J. B. / Regulation of human B lymphocyte responsiveness. In: Scandinavian Journal of Rheumatology, Supplement. 1988 ; Vol. 76. pp. 229-235.
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