Abstract
Histone genes are expressed during the S phase of the cell cycle. Control is at multiple levels and is mediated by the integration of regulatory signals in response to cell-cycle progression and the onset of differentiation. Much work has been carried out on the H4 gene promoter, which appears to be organized into a series of distinct regulatory elements. The three-dimensional organization of the promoter and, in particular, its spatial relationship with the nuclear matrix scaffold, may be important factors of transcription regulation.
Original language | English (US) |
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Pages (from-to) | 166-173 |
Number of pages | 8 |
Journal | Current Opinion in Cell Biology |
Volume | 4 |
Issue number | 2 |
DOIs | |
State | Published - Apr 1992 |
ASJC Scopus subject areas
- Cell Biology