Regulation of histone gene expression

Gary S. Stein, Janet L. Stein, Andre J. van Wijnen, Jane B. Lian

Research output: Contribution to journalArticle

62 Scopus citations


Histone genes are expressed during the S phase of the cell cycle. Control is at multiple levels and is mediated by the integration of regulatory signals in response to cell-cycle progression and the onset of differentiation. Much work has been carried out on the H4 gene promoter, which appears to be organized into a series of distinct regulatory elements. The three-dimensional organization of the promoter and, in particular, its spatial relationship with the nuclear matrix scaffold, may be important factors of transcription regulation.

Original languageEnglish (US)
Pages (from-to)166-173
Number of pages8
JournalCurrent Opinion in Cell Biology
Issue number2
StatePublished - Apr 1992


ASJC Scopus subject areas

  • Cell Biology

Cite this

Stein, G. S., Stein, J. L., van Wijnen, A. J., & Lian, J. B. (1992). Regulation of histone gene expression. Current Opinion in Cell Biology, 4(2), 166-173.