TY - JOUR
T1 - Regulation of force in vascular smooth muscle
AU - Ogut, Ozgur
AU - Brozovich, Frank V.
N1 - Funding Information:
This work was supported by grants from the American Heart Association (0120359B to O.O.) and National Institutes of Health (HL44181, HL64137 to F.V.B.).
PY - 2003/4/1
Y1 - 2003/4/1
N2 - Vascular smooth muscle contraction plays a defining role in the regulation and maintenance of blood pressure, and its deregulation is associated with many clinical syndromes including hypertension, coronary vasospasm and congestive heart failure. Over the past 20 years, there has been a growing understanding of the regulation of 20 kDa myosin light chain phosphorylation by myosin light chain kinase and myosin light chain phosphatase, the role of splice-variant isoforms of both the myosin heavy chain and the essential myosin light chain, as well as the signaling pathways involved in smooth muscle contraction under normal and pathophysiological conditions. This review will attempt to recapitulate the data in the field, primarily focusing on the contractile response of smooth muscle, and the molecular determinants responsible for the regulation of vascular tone.
AB - Vascular smooth muscle contraction plays a defining role in the regulation and maintenance of blood pressure, and its deregulation is associated with many clinical syndromes including hypertension, coronary vasospasm and congestive heart failure. Over the past 20 years, there has been a growing understanding of the regulation of 20 kDa myosin light chain phosphorylation by myosin light chain kinase and myosin light chain phosphatase, the role of splice-variant isoforms of both the myosin heavy chain and the essential myosin light chain, as well as the signaling pathways involved in smooth muscle contraction under normal and pathophysiological conditions. This review will attempt to recapitulate the data in the field, primarily focusing on the contractile response of smooth muscle, and the molecular determinants responsible for the regulation of vascular tone.
UR - http://www.scopus.com/inward/record.url?scp=0037384395&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037384395&partnerID=8YFLogxK
U2 - 10.1016/S0022-2828(03)00045-2
DO - 10.1016/S0022-2828(03)00045-2
M3 - Review article
C2 - 12689814
AN - SCOPUS:0037384395
VL - 35
SP - 347
EP - 355
JO - Journal of Molecular and Cellular Cardiology
JF - Journal of Molecular and Cellular Cardiology
SN - 0022-2828
IS - 4
ER -