Regulation of force in vascular smooth muscle

Ozgur Ogut, Frank V. Brozovich

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

Vascular smooth muscle contraction plays a defining role in the regulation and maintenance of blood pressure, and its deregulation is associated with many clinical syndromes including hypertension, coronary vasospasm and congestive heart failure. Over the past 20 years, there has been a growing understanding of the regulation of 20 kDa myosin light chain phosphorylation by myosin light chain kinase and myosin light chain phosphatase, the role of splice-variant isoforms of both the myosin heavy chain and the essential myosin light chain, as well as the signaling pathways involved in smooth muscle contraction under normal and pathophysiological conditions. This review will attempt to recapitulate the data in the field, primarily focusing on the contractile response of smooth muscle, and the molecular determinants responsible for the regulation of vascular tone.

Original languageEnglish (US)
Pages (from-to)347-355
Number of pages9
JournalJournal of Molecular and Cellular Cardiology
Volume35
Issue number4
DOIs
StatePublished - Apr 1 2003
Externally publishedYes

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ASJC Scopus subject areas

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

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