REGULATION OF EXPERIMENTAL AUTOIMMUNE THYROIDITIS: INFLUENCE OF NON‐H‐2 GENES

K. W. Beisel, Y. M. Kong, K. S.J. Babu, C. S. David, N. R. Rose

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Experiments were conducted to investigate the non‐H‐2 genetic effects on experimental autoimmune thyroiditis (EAT). Strains having C3H or BALB backgroud in general produced higher autoimmune responses to mouse thyroglobulin (MTg) than the B10 or A strains. Comparisons of C3H and B10 congenic strains carrying similar H‐2 haplotypes demonstrated that the C3H congenics had significantly higher MTg antibody titres and more severe thyroid damage, even when the strains carry the low responder H‐2 haplotypes. These observations show that non‐H‐2 gene(s) influences EAT, in addition to genes in the MHC.

Original languageEnglish (US)
Pages (from-to)257-265
Number of pages9
JournalInternational Journal of Immunogenetics
Volume9
Issue number4
DOIs
StatePublished - Aug 1982

ASJC Scopus subject areas

  • Immunology
  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Fingerprint Dive into the research topics of 'REGULATION OF EXPERIMENTAL AUTOIMMUNE THYROIDITIS: INFLUENCE OF NON‐H‐2 GENES'. Together they form a unique fingerprint.

  • Cite this