Regulation of eukaryotic cell differentiation by long Non-coding RNAs

Juan R. Alvarez-Dominguez, Wengian Hu, Harvey F. Lodish

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides that do not have functional protein-coding capacity. They can regulate gene expression by affecting the transcription, translation, and stability of mRNA targets through diverse mechanisms. Dozens of eukaryotic lncRNAs have been functionally characterized to date, and they have been associated with important cellular processes such as meiosis, pluripotency, apoptosis, and lineage specification. An emerging theme among known lncRNA functions is therefore the modulation of cell differentiation states, often in response to developmental or environmental cues. This chapter discusses current models of lncRNA function during several well-characterized cell differentiation processes, from yeast to human, highlighting recent evidence that implicate lncRNAs in the regulation of animal development.

Original languageEnglish (US)
Title of host publicationMolecular Biology of Long Non-Coding RNAs
PublisherSpringer New York
Pages15-67
Number of pages53
ISBN (Electronic)9781461486213
ISBN (Print)1461486203, 9781461486206
DOIs
StatePublished - Nov 1 2013
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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