Regulation of complex pulsatile and rhythmic neuroendocrine systems: The male gonadal axis as a prototype

Johannes D. Veldhuis; Daniel M. Keenan; Steven M. Pincus

doi:10.1016/S0079-6123(08)81006-0

Regulation of complex pulsatile and rhythmic neuroendocrine systems: The male gonadal axis as a prototype

Johannes D. Veldhuis, Daniel M. Keenan, Steven M. Pincus

Endocrinology, Diabetes, Metabolism, and Nutrition

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Hormone-secreting glands communicate via intermittent (pulsatile or rhythmic) signal exchange. Signals act upon target glands via implicit (not directly observable) stimulatory and inhibitory dose-response functions. Time delays operate, since secreted hormones do not arrive at or act on responsive cells instantaneously. Neuroendocrine systems are unique examples, therefore, of intermittent time-delayed dose-dependent homeostatic ensembles. Investigating such ensembles thus requires estimating secretion from plasma concentrations, recognizing biological time-delays and reconstructing unobserved feedforward (agonist) and feedback (antagonist) dose-response interfaces as illustrated primarily for the GnRH-LH-T-axis, and secondarily for the corticotropic and somatotropic axes. In this manner, each neuroendocrine system is viewed as a whole, rather than the sum of individual parts.

Original language	English (US)
Pages (from-to)	79-110
Number of pages	32
Journal	Progress in Brain Research
Volume	181
Issue number	C
DOIs	https://doi.org/10.1016/S0079-6123(08)81006-0
State	Published - 2010

Keywords

Acth
Cortisol
Gh
Lh
Pulses
Rhythms
Secretion
Testosterone

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/S0079-6123(08)81006-0

Cite this

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title = "Regulation of complex pulsatile and rhythmic neuroendocrine systems: The male gonadal axis as a prototype",

abstract = "Hormone-secreting glands communicate via intermittent (pulsatile or rhythmic) signal exchange. Signals act upon target glands via implicit (not directly observable) stimulatory and inhibitory dose-response functions. Time delays operate, since secreted hormones do not arrive at or act on responsive cells instantaneously. Neuroendocrine systems are unique examples, therefore, of intermittent time-delayed dose-dependent homeostatic ensembles. Investigating such ensembles thus requires estimating secretion from plasma concentrations, recognizing biological time-delays and reconstructing unobserved feedforward (agonist) and feedback (antagonist) dose-response interfaces as illustrated primarily for the GnRH-LH-T-axis, and secondarily for the corticotropic and somatotropic axes. In this manner, each neuroendocrine system is viewed as a whole, rather than the sum of individual parts.",

keywords = "Acth, Cortisol, Gh, Lh, Pulses, Rhythms, Secretion, Testosterone",

author = "Veldhuis, {Johannes D.} and Keenan, {Daniel M.} and Pincus, {Steven M.}",

note = "Funding Information: We thank Donna Scott for support of manuscript preparation and Ashley Bryant for data analysis and graphics. Supported in part via the Clinical Translational Research Center Grant MO1 RR00585 to the Mayo Clinic and Foundation from the National Center for Research Resources (Rockville, MD) and R01 NIA AG019695, AG23133, AG29362, DK73148 and R21 AG29215 and AG23777 from the National Institutes of Health (Bethesda, MD).",

year = "2010",

doi = "10.1016/S0079-6123(08)81006-0",

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AU - Pincus, Steven M.

N1 - Funding Information: We thank Donna Scott for support of manuscript preparation and Ashley Bryant for data analysis and graphics. Supported in part via the Clinical Translational Research Center Grant MO1 RR00585 to the Mayo Clinic and Foundation from the National Center for Research Resources (Rockville, MD) and R01 NIA AG019695, AG23133, AG29362, DK73148 and R21 AG29215 and AG23777 from the National Institutes of Health (Bethesda, MD).

PY - 2010

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N2 - Hormone-secreting glands communicate via intermittent (pulsatile or rhythmic) signal exchange. Signals act upon target glands via implicit (not directly observable) stimulatory and inhibitory dose-response functions. Time delays operate, since secreted hormones do not arrive at or act on responsive cells instantaneously. Neuroendocrine systems are unique examples, therefore, of intermittent time-delayed dose-dependent homeostatic ensembles. Investigating such ensembles thus requires estimating secretion from plasma concentrations, recognizing biological time-delays and reconstructing unobserved feedforward (agonist) and feedback (antagonist) dose-response interfaces as illustrated primarily for the GnRH-LH-T-axis, and secondarily for the corticotropic and somatotropic axes. In this manner, each neuroendocrine system is viewed as a whole, rather than the sum of individual parts.

AB - Hormone-secreting glands communicate via intermittent (pulsatile or rhythmic) signal exchange. Signals act upon target glands via implicit (not directly observable) stimulatory and inhibitory dose-response functions. Time delays operate, since secreted hormones do not arrive at or act on responsive cells instantaneously. Neuroendocrine systems are unique examples, therefore, of intermittent time-delayed dose-dependent homeostatic ensembles. Investigating such ensembles thus requires estimating secretion from plasma concentrations, recognizing biological time-delays and reconstructing unobserved feedforward (agonist) and feedback (antagonist) dose-response interfaces as illustrated primarily for the GnRH-LH-T-axis, and secondarily for the corticotropic and somatotropic axes. In this manner, each neuroendocrine system is viewed as a whole, rather than the sum of individual parts.

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Regulation of complex pulsatile and rhythmic neuroendocrine systems: The male gonadal axis as a prototype

Abstract

Keywords

ASJC Scopus subject areas

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