Many questions remain unanswered about regulation of catecholamine biosynthesis. The cell culture system of mouse neuroblastoma was used, and in particular, the adrenergic clone N1E115 was studied. This clone transports catechol precursors phenylalanine and tyrosine by high affinity mechanisms; and regulates tyrosine hydroxylase activity which is stimulated by dibutyryl cyclic AMP. In addition, this clone forms neurites and has electrically excitable membranes. Since these properties reflect in vivo processes, N1E115 may be a useful model system for the elucidation of some of the mechanisms involved in the regulation of catecholamine biosynthesis.
|Original language||English (US)|
|Number of pages||7|
|Issue number||sup 1|
|State||Published - 1974|
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