Regulation of bone metabolism by sex steroids

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

Osteoporosis is a significant public health problem, and a major cause of the disease is estrogen deficiency following menopause in women. In addition, considerable evidence now shows that estrogen is also a major regulator of bone metabolism in men. Since the original description of the effects of estrogen deficiency on bone by Fuller Albright more than 70 years ago, there has been enormous progress in understanding the mechanisms of estrogen and testosterone action on bone using human and mouse models. Although we understand more about the effects of estrogen on bone as compared with testosterone, both sex steroids do play important roles, perhaps in a somewhat compartment-specific (i.e., cancellous vs. cortical bone) manner. This review summarizes our current knowledge of sex steroid action on bone based on human and mouse studies, identifies both agreements and potential discrepancies between these studies, and suggests directions for future research in this important area.

Original languageEnglish (US)
Article numbera031211
JournalCold Spring Harbor perspectives in medicine
Volume8
Issue number1
DOIs
StatePublished - Jan 1 2018

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Metabolism
Bone
Estrogens
Steroids
Bone and Bones
Testosterone
Menopause
Osteoporosis
Public health
Medical problems
Public Health

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Regulation of bone metabolism by sex steroids. / Khosla, Sundeep; Monroe, David G.

In: Cold Spring Harbor perspectives in medicine, Vol. 8, No. 1, a031211, 01.01.2018.

Research output: Contribution to journalReview article

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