Regulation of blood pressure by the arterial baroreflex and autonomic nervous system

Erica A. Wehrwein, Michael J. Joyner

Research output: Chapter in Book/Report/Conference proceedingChapter

53 Scopus citations

Abstract

Mean arterial pressure (MAP) is a critical hemodynamic factor. The absence of proper regulation of MAP can have important pathophysiological consequences. Low MAP can cause inadequate blood flow to organs, syncope, and shock. On the other hand, elevated MAP contributes to increased oxygen demand by the heart, ventricular remodeling, vascular injury, end organ damage, and stroke. The arterial baroreflex system is a key controller of MAP and is a complex system. It can be considered in its entirety as an integrative physiological system or in terms of its regulated component parts. Those component parts include MAP, mechanosensory transduction, afferent pathways, central neural circuits, efferent pathways, receptor pharmacology, integration with other key homeostatic inputs, molecular biology, and/or other elements. This chapter provides an overview of each of these individual components but stresses the importance of the integrative nature of this reflex. In addition, this chapter explores common measurement techniques for the baroreflex and explores the baroreflex in diseases.

Original languageEnglish (US)
Title of host publicationHandbook of Clinical Neurology
PublisherElsevier B.V.
Pages89-102
Number of pages14
DOIs
StatePublished - 2013

Publication series

NameHandbook of Clinical Neurology
Volume117
ISSN (Print)0072-9752

Keywords

  • Autonomic
  • Baroreceptors
  • Baroreflex
  • Baroreflex sensitivity
  • Mean arterial pressure
  • Sympathetic

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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