Regulation of autoimmune response to mouse thyroglobulin: Influence of H-2D-end genes

Y. C.M. Kong, C. S. David, A. A. Giraldo, M. Elrehewy, N. R. Rose

Research output: Contribution to journalArticle

121 Scopus citations

Abstract

Studies were initiated to define the H-2-linked genetic control of response to self-determinants of MTg. In addition to the Ir gene control of H-2K end, a modifying effect of D end was seen. The extent of regulation depended upon the derivation of the K-end Ir-Tg gene(s) as well as the D-end genes. When the Ir-Tg gene was from good responder H-2(k) and H-S(s) strains, and the H-2D-end gene from the d allele, antibody levels were moderate to high but cellular infiltration was significantly reduced. These findings demonstrate genetic interaction between I-region and D-end gene products in the response to a self-antigen, MTg.

Original languageEnglish (US)
Pages (from-to)15-18
Number of pages4
JournalJournal of Immunology
Volume123
Issue number1
StatePublished - Dec 1 1979

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Kong, Y. C. M., David, C. S., Giraldo, A. A., Elrehewy, M., & Rose, N. R. (1979). Regulation of autoimmune response to mouse thyroglobulin: Influence of H-2D-end genes. Journal of Immunology, 123(1), 15-18.