Regional ventilation during spontaneous breathing and mechanical ventilation in dogs

R. D. Hubmayr, J. R. Rodarte, B. J. Walters, F. M. Tonelli

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

We evaluated the effects of the different patterns of chest wall deformation that occur with different body positions and modes of breathing on regional lung deformation and ventilation. Using the parenchymal marker technique, we determined regional lung behavior during mechanical ventilation and spontaneous breathing in five anesthetized recumbent dogs. Regional lung behavior was related to the patterns of diaphragm motion estimated from X-ray projection images obtained at functional residual capacity (FRC) and end inspiration. Our results indicate that 1) in the prone and supine positions, FRC was larger during mechanical ventilation than during spontaneous breathing; 2) there were significant differences in the patterns of diaphragm motion and regional ventilation between mechanical ventilation and spontaneous breathing in both positions; 3) in the supine position only, there was a vertical gradient in lung volume at FRC; 4) in both positions and for both modes of breathing, regional ventilation was nonlinearly related to changes in lobar and overall lung volumes; and 5) different patterns of diaphragm motion caused different sliding motions and differential rotations of upper and lower lobes. Our results are inconsistent with the classic model of regional ventilation, and we conclude that the distribution of ventilation is determined by a complex interaction of lung and chest wall shapes and by the motion of the lobes relative to each other, all of which help to minimize distortion of the lung parenchyma.

Original languageEnglish (US)
Pages (from-to)2467-2475
Number of pages9
JournalJournal of Applied Physiology
Volume63
Issue number6
StatePublished - 1987

Fingerprint

Artificial Respiration
Ventilation
Respiration
Dogs
Lung
Functional Residual Capacity
Diaphragm
Supine Position
Thoracic Wall
Prone Position
X-Rays

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Hubmayr, R. D., Rodarte, J. R., Walters, B. J., & Tonelli, F. M. (1987). Regional ventilation during spontaneous breathing and mechanical ventilation in dogs. Journal of Applied Physiology, 63(6), 2467-2475.

Regional ventilation during spontaneous breathing and mechanical ventilation in dogs. / Hubmayr, R. D.; Rodarte, J. R.; Walters, B. J.; Tonelli, F. M.

In: Journal of Applied Physiology, Vol. 63, No. 6, 1987, p. 2467-2475.

Research output: Contribution to journalArticle

Hubmayr, RD, Rodarte, JR, Walters, BJ & Tonelli, FM 1987, 'Regional ventilation during spontaneous breathing and mechanical ventilation in dogs', Journal of Applied Physiology, vol. 63, no. 6, pp. 2467-2475.
Hubmayr, R. D. ; Rodarte, J. R. ; Walters, B. J. ; Tonelli, F. M. / Regional ventilation during spontaneous breathing and mechanical ventilation in dogs. In: Journal of Applied Physiology. 1987 ; Vol. 63, No. 6. pp. 2467-2475.
@article{b05c5f667e6c44b3870d66766cf52002,
title = "Regional ventilation during spontaneous breathing and mechanical ventilation in dogs",
abstract = "We evaluated the effects of the different patterns of chest wall deformation that occur with different body positions and modes of breathing on regional lung deformation and ventilation. Using the parenchymal marker technique, we determined regional lung behavior during mechanical ventilation and spontaneous breathing in five anesthetized recumbent dogs. Regional lung behavior was related to the patterns of diaphragm motion estimated from X-ray projection images obtained at functional residual capacity (FRC) and end inspiration. Our results indicate that 1) in the prone and supine positions, FRC was larger during mechanical ventilation than during spontaneous breathing; 2) there were significant differences in the patterns of diaphragm motion and regional ventilation between mechanical ventilation and spontaneous breathing in both positions; 3) in the supine position only, there was a vertical gradient in lung volume at FRC; 4) in both positions and for both modes of breathing, regional ventilation was nonlinearly related to changes in lobar and overall lung volumes; and 5) different patterns of diaphragm motion caused different sliding motions and differential rotations of upper and lower lobes. Our results are inconsistent with the classic model of regional ventilation, and we conclude that the distribution of ventilation is determined by a complex interaction of lung and chest wall shapes and by the motion of the lobes relative to each other, all of which help to minimize distortion of the lung parenchyma.",
author = "Hubmayr, {R. D.} and Rodarte, {J. R.} and Walters, {B. J.} and Tonelli, {F. M.}",
year = "1987",
language = "English (US)",
volume = "63",
pages = "2467--2475",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "6",

}

TY - JOUR

T1 - Regional ventilation during spontaneous breathing and mechanical ventilation in dogs

AU - Hubmayr, R. D.

AU - Rodarte, J. R.

AU - Walters, B. J.

AU - Tonelli, F. M.

PY - 1987

Y1 - 1987

N2 - We evaluated the effects of the different patterns of chest wall deformation that occur with different body positions and modes of breathing on regional lung deformation and ventilation. Using the parenchymal marker technique, we determined regional lung behavior during mechanical ventilation and spontaneous breathing in five anesthetized recumbent dogs. Regional lung behavior was related to the patterns of diaphragm motion estimated from X-ray projection images obtained at functional residual capacity (FRC) and end inspiration. Our results indicate that 1) in the prone and supine positions, FRC was larger during mechanical ventilation than during spontaneous breathing; 2) there were significant differences in the patterns of diaphragm motion and regional ventilation between mechanical ventilation and spontaneous breathing in both positions; 3) in the supine position only, there was a vertical gradient in lung volume at FRC; 4) in both positions and for both modes of breathing, regional ventilation was nonlinearly related to changes in lobar and overall lung volumes; and 5) different patterns of diaphragm motion caused different sliding motions and differential rotations of upper and lower lobes. Our results are inconsistent with the classic model of regional ventilation, and we conclude that the distribution of ventilation is determined by a complex interaction of lung and chest wall shapes and by the motion of the lobes relative to each other, all of which help to minimize distortion of the lung parenchyma.

AB - We evaluated the effects of the different patterns of chest wall deformation that occur with different body positions and modes of breathing on regional lung deformation and ventilation. Using the parenchymal marker technique, we determined regional lung behavior during mechanical ventilation and spontaneous breathing in five anesthetized recumbent dogs. Regional lung behavior was related to the patterns of diaphragm motion estimated from X-ray projection images obtained at functional residual capacity (FRC) and end inspiration. Our results indicate that 1) in the prone and supine positions, FRC was larger during mechanical ventilation than during spontaneous breathing; 2) there were significant differences in the patterns of diaphragm motion and regional ventilation between mechanical ventilation and spontaneous breathing in both positions; 3) in the supine position only, there was a vertical gradient in lung volume at FRC; 4) in both positions and for both modes of breathing, regional ventilation was nonlinearly related to changes in lobar and overall lung volumes; and 5) different patterns of diaphragm motion caused different sliding motions and differential rotations of upper and lower lobes. Our results are inconsistent with the classic model of regional ventilation, and we conclude that the distribution of ventilation is determined by a complex interaction of lung and chest wall shapes and by the motion of the lobes relative to each other, all of which help to minimize distortion of the lung parenchyma.

UR - http://www.scopus.com/inward/record.url?scp=0023574785&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023574785&partnerID=8YFLogxK

M3 - Article

C2 - 3436878

AN - SCOPUS:0023574785

VL - 63

SP - 2467

EP - 2475

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 6

ER -