Regional proton magnetic resonance spectroscopy patterns in dementia with Lewy bodies

Jonathan Graff-Radford, Bradley F Boeve, Melissa E Murray, Tanis Jill Ferman, Nirubol Tosakulwong, Timothy G. Lesnick, Mandie Maroney-Smith, Matthew L. Senjem, Jeffrey Gunter, Glenn E. Smith, David S Knopman, Clifford R Jr. Jack, Dennis W Dickson, Ronald Carl Petersen, Kejal M Kantarci

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Magnetic resonance spectroscopy (MRS) characteristics of dementia with Lewy bodies (DLB) Alzheimer's disease (AD) and cognitively normal controls were compared. DLB (n= 34), AD (n= 35), and cognitively normal controls (n= 148) participated in a MRS study from frontal, posterior cingulate, and occipital voxels. We investigated DLB patients with preserved hippocampal volumes to determine the MRS changes in DLB with low probability of overlapping AD pathology. DLB patients were characterized by decreased N-acetylaspartate/creatine (NAA/Cr) in the occipital voxel. AD patients were characterized by lower NAA/Cr in the frontal and posterior cingulate voxels. Normal NAA/Cr levels in the frontal voxel differentiated DLB patients with preserved hippocampal volumes from AD patients. DLB and AD patients had elevated choline/creatine, and myo-Inositol/creatine in the posterior cingulate. MRS abnormalities associated with loss of neuronal integrity localized to the occipital lobes in DLB, and the posterior cingulate gyri and frontal lobes in AD. This pattern of MRS abnormalities may have a role in differential diagnosis of DLB and in distinguishing DLB patients with overlapping AD pathology.

Original languageEnglish (US)
Pages (from-to)1483-1490
Number of pages8
JournalNeurobiology of Aging
Volume35
Issue number6
DOIs
StatePublished - Jun 2014

Fingerprint

Lewy Body Disease
Alzheimer Disease
Creatine
Gyrus Cinguli
Magnetic Resonance Spectroscopy
Dementia
Proton Magnetic Resonance Spectroscopy
Pathology
Occipital Lobe
Frontal Lobe
Inositol
Choline
Differential Diagnosis

Keywords

  • Alzheimer's disease
  • Dementia with Lewy bodies
  • Magnetic resonance spectroscopy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Aging
  • Developmental Biology
  • Geriatrics and Gerontology
  • Medicine(all)

Cite this

Regional proton magnetic resonance spectroscopy patterns in dementia with Lewy bodies. / Graff-Radford, Jonathan; Boeve, Bradley F; Murray, Melissa E; Ferman, Tanis Jill; Tosakulwong, Nirubol; Lesnick, Timothy G.; Maroney-Smith, Mandie; Senjem, Matthew L.; Gunter, Jeffrey; Smith, Glenn E.; Knopman, David S; Jack, Clifford R Jr.; Dickson, Dennis W; Petersen, Ronald Carl; Kantarci, Kejal M.

In: Neurobiology of Aging, Vol. 35, No. 6, 06.2014, p. 1483-1490.

Research output: Contribution to journalArticle

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