Regional network of magnetic resonance imaging gray matter volume in healthy aging

Gene E. Alexander, Kewei Chen, Tricia L. Merkley, Eric M. Reiman, Richard John Caselli, Melaney Aschenbrenner, Laura Santerre-Lemmon, Diana J. Lewis, Pietro Pietrini, Stefan J. Teipel, Harald Hampel, Stanley I. Rapoport, James R. Moeller

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Healthy aging has been associated with brain volume reductions preferentially affecting the frontal cortex, but also involving other regions. We used a network model of regional covariance, the Scaled Subprofile Model, with magnetic resonance imaging voxel-based morphometry to identify the regional distribution of gray matter associated with aging in 26 healthy adults, 22-77 years old. Scaled Subprofile Model analysis identified a pattern that was highly correlated with age (R2=0.66, P≤0.0001). Older age was associated with less gray matter in the bilateral frontal, temporal,thalamic, and right cerebellar regions. Gender differences suggested more advanced brain aging in the men. In this healthy adult sample, aging was associated with a regional pattern of gray matter atrophy most prominently involving the frontal and temporal cortices. Scaled Subprofile Model network analysis may aid in the detection and tracking of brain aging and in the evaluation of putative antiaging therapies.

Original languageEnglish (US)
Pages (from-to)951-956
Number of pages6
JournalNeuroReport
Volume17
Issue number10
DOIs
StatePublished - Jun 2006

Fingerprint

Magnetic Resonance Imaging
Frontal Lobe
Brain
Temporal Lobe
Atrophy
Gray Matter
Therapeutics

Keywords

  • Aging
  • Gray matter
  • Magnetic resonance imaging
  • Multivariate analysis
  • Principal component analysis
  • Scaled Subprofile Model
  • Voxel-based morphometry

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Alexander, G. E., Chen, K., Merkley, T. L., Reiman, E. M., Caselli, R. J., Aschenbrenner, M., ... Moeller, J. R. (2006). Regional network of magnetic resonance imaging gray matter volume in healthy aging. NeuroReport, 17(10), 951-956. https://doi.org/10.1097/01.wnr.0000220135.16844.b6

Regional network of magnetic resonance imaging gray matter volume in healthy aging. / Alexander, Gene E.; Chen, Kewei; Merkley, Tricia L.; Reiman, Eric M.; Caselli, Richard John; Aschenbrenner, Melaney; Santerre-Lemmon, Laura; Lewis, Diana J.; Pietrini, Pietro; Teipel, Stefan J.; Hampel, Harald; Rapoport, Stanley I.; Moeller, James R.

In: NeuroReport, Vol. 17, No. 10, 06.2006, p. 951-956.

Research output: Contribution to journalArticle

Alexander, GE, Chen, K, Merkley, TL, Reiman, EM, Caselli, RJ, Aschenbrenner, M, Santerre-Lemmon, L, Lewis, DJ, Pietrini, P, Teipel, SJ, Hampel, H, Rapoport, SI & Moeller, JR 2006, 'Regional network of magnetic resonance imaging gray matter volume in healthy aging', NeuroReport, vol. 17, no. 10, pp. 951-956. https://doi.org/10.1097/01.wnr.0000220135.16844.b6
Alexander, Gene E. ; Chen, Kewei ; Merkley, Tricia L. ; Reiman, Eric M. ; Caselli, Richard John ; Aschenbrenner, Melaney ; Santerre-Lemmon, Laura ; Lewis, Diana J. ; Pietrini, Pietro ; Teipel, Stefan J. ; Hampel, Harald ; Rapoport, Stanley I. ; Moeller, James R. / Regional network of magnetic resonance imaging gray matter volume in healthy aging. In: NeuroReport. 2006 ; Vol. 17, No. 10. pp. 951-956.
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