Regional lipolytic responses to isoproterenol in women

Zengkui Guo, C. Michael Johnson, Michael Dennis Jensen

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

We previously found that epinephrine, a mixed β- and α-adrenoreceptor agonist, stimulates systemic and nonsplanchnic upper body free fatty acid (FFA) release but not lower body FFA release in healthy nonobese women. To evaluate the role of β-adrenergic-mediated effects on this regional difference in lipolysis, we measured systemic, leg, and splanchnic FFA kinetics ([3H]palmitate) in seven healthy nonobese women before and during an intravenous isoproterenol infusion. Isoproterenol increased systemic palmitate flux (87 ± 12 vs. 100 ± 10 μmo/min, P < 0.05) but failed to affect leg [10.8 ± 1.2 vs. 11.4 ± 2.3 μmol/min, P = not significant (NS)] or splanchnic (10.8 ± 3.2 vs. 10.0 ± 1.8 μmol/min, P = NS) palmitate release. Upper body nonsplanchnic palmitate release increased from 56 ± 14 to 71 ± 10 μmol/min. Systemic O2 consumption increased (227 ± 11 to 241 ± 10 ml/min, P = 0.006) during isoproterenol infusion, as did leg (318 ± 42 vs. 404 ± 53 ml/min, P < 0.01) and splanchnic (827 ± 104 vs. 970 ± 108 ml/min, P < 0.05) plasma flow. These results suggest that lower body adipose tissue lipolysis in women is less sensitive or responsive than nonsplanchnic upper body adipose tissue to β-adrenergic stimulation and that regional differences in α2-adrenergic-receptor responses were not responsible for the similar regional differences we observed previously with epinephrine.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume273
Issue number1 36-1
StatePublished - Jul 1997

Fingerprint

Palmitates
Isoproterenol
Viscera
Nonesterified Fatty Acids
Leg
Lipolysis
Adrenergic Agents
Epinephrine
Adipose Tissue
Tissue
Plasma flow
Intravenous Infusions
Adrenergic Receptors
Fluxes
Kinetics

Keywords

  • Blood flow
  • Body composition
  • Free fatty acids
  • Isotope dilution
  • Palmitate

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Biochemistry
  • Physiology (medical)

Cite this

Regional lipolytic responses to isoproterenol in women. / Guo, Zengkui; Johnson, C. Michael; Jensen, Michael Dennis.

In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 273, No. 1 36-1, 07.1997.

Research output: Contribution to journalArticle

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