TY - JOUR
T1 - Regional Diastolic Contour Abnormalities During Contrast Stress Echocardiography
T2 - Improved Detection of Coronary Artery Disease
AU - Cukon-Buttignoni, Sonja
AU - Abdelmoneim, Sahar S.
AU - Ehrsam, Jo Ellen
AU - Barnes, Marion E.
AU - Hagen, Mary E.
AU - Carlson, Lori A.
AU - Iliceto, Sabino
AU - Mulvagh, Sharon L.
PY - 2008/10
Y1 - 2008/10
N2 - Background: Use of contrast improves detection of systolic regional wall motion abnormalities (RWMAs) during stress echocardiography. We evaluated regional diastolic contour abnormalities (RDCAs) that were associated with coronary artery disease (CAD). Methods: From August of 2003 to September of 2004, we evaluated 89 patients who underwent contrast stress echocardiography (CSE) and coronary angiography within a 3-month period ("invasive" group) and 17 patients with lower CAD risk who underwent CSE only ("reference" group). Results: RDCAs were present in 73 patients in the invasive group and were associated with higher Framingham risk scores (relative risk, 3.6; 95% confidence interval, 1.9-6.6). RDCAs were present in 1 patient in the reference group. When combined with RWMA, RDCA improved sensitivity of CSE from 78% to 97% and specificity from 26% to 59% (diagnostic threshold for CAD was 70% stenosis). Conclusion: RDCAs were a novel observation associated with higher CAD risk and improved the diagnostic accuracy of CSE.
AB - Background: Use of contrast improves detection of systolic regional wall motion abnormalities (RWMAs) during stress echocardiography. We evaluated regional diastolic contour abnormalities (RDCAs) that were associated with coronary artery disease (CAD). Methods: From August of 2003 to September of 2004, we evaluated 89 patients who underwent contrast stress echocardiography (CSE) and coronary angiography within a 3-month period ("invasive" group) and 17 patients with lower CAD risk who underwent CSE only ("reference" group). Results: RDCAs were present in 73 patients in the invasive group and were associated with higher Framingham risk scores (relative risk, 3.6; 95% confidence interval, 1.9-6.6). RDCAs were present in 1 patient in the reference group. When combined with RWMA, RDCA improved sensitivity of CSE from 78% to 97% and specificity from 26% to 59% (diagnostic threshold for CAD was 70% stenosis). Conclusion: RDCAs were a novel observation associated with higher CAD risk and improved the diagnostic accuracy of CSE.
KW - Cardiovascular risk
KW - Contrast echocardiography
KW - Coronary artery disease
KW - Stress echocardiography
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U2 - 10.1016/j.echo.2008.07.018
DO - 10.1016/j.echo.2008.07.018
M3 - Article
C2 - 18926388
AN - SCOPUS:52949090843
SN - 0894-7317
VL - 21
SP - 1109
EP - 1115
JO - Journal of the American Society of Echocardiography
JF - Journal of the American Society of Echocardiography
IS - 10
ER -