Regional cyst concentration as a prognostic biomarker for polycystic kidney disease

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Polycystic kidney disease (PKD) is a major cause of renal failure. Despite recent advances in understanding the biochemistry and genetics of PKD, the functional mechanisms underpinning the declines in renal function observed in the disorder are not well established. No studies investigating the distribution of cysts within polycystic kidneys exist. This work introduces regional cyst concentration as a new biomarker for evaluation of patients suffering from PKD. We derive a method to define central and peripheral regions of the kidney, approximating the anatomical division between cortex and medulla, and apply it to two cohorts of ten patients with early/mild or late/severe disease. Our results from the late/severe cohort show peripheral cyst concentration correlates with the current standard PKD biomarker, total kidney volume (TKV), signi cantly better than central cyst concentration (p < 0.05). We also find that cyst concentration was globally increased in the late/severe cohort (p << 0.01) compared to the early/mild cohort, for both central and peripheral regions. These findings show cysts in PKD are not distributed homogeneously throughout the renal tissues.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2014
Subtitle of host publicationBiomedical Applications in Molecular, Structural, and Functional Imaging
PublisherSPIE
ISBN (Print)9780819498311
DOIs
StatePublished - Jan 1 2014
EventMedical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging - San Diego, CA, United States
Duration: Feb 16 2014Feb 18 2014

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9038
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging
CountryUnited States
CitySan Diego, CA
Period2/16/142/18/14

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Keywords

  • ADPKD
  • Biomarker
  • Cyst concentration
  • Cyst distribution
  • Image analysis
  • MRI
  • Polycystic kidney disease
  • Quantitative imaging

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Warner, J. D., Irazabal, M. V., Torres, V. E., King, B. F., & Erickson, B. J. (2014). Regional cyst concentration as a prognostic biomarker for polycystic kidney disease. In Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging [903804] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9038). SPIE. https://doi.org/10.1117/12.2044220