Regional cortical thinning in multiple sclerosis and its relation with cognitive impairment: A multicenter study

Jan-Mendelt Tillema, H. E. Hulst, M. A. Rocca, H. Vrenken, M. D. Steenwijk, D. Damjanovic, C. Enzinger, S. Ropele, G. Tedeschi, A. Gallo, O. Ciccarelli, A. Rovira, X. Montalban, N. De Stefano, M. L. Stromillo, M. Filippi, F. Barkhof

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objectives: The objectives of this paper are to compare in a multicenter setting patterns of regional cortical thickness in patients with relapsing-remitting multiple sclerosis (RRMS) and cognitive impairment (CI) and those cognitively preserved (CP), and explore the relationship between cortical thinning and cognitive performance. Methods: T1-weighted isotropic brain scans were collected at 3T from seven European centers in 60 RRMS patients and 65 healthy controls (HCs). Patients underwent clinical and neuropsychological examinations. Cortical thickness (CTh) measures were calculated using FreeSurfer (failing in four) and both lobar and vertex-based general linear model (GLM) analyses were compared between study groups. Results: Twenty (36%) MS patients were classified as CI. Mean global CTh was smaller in RRMS patients compared to HCs (left 2.43 vs. 2.53 mm, right 2.44 vs. 2.54 mm, p < 0.001). Multivariate GLM regional analysis showed significantly more temporal thinning in CI compared to CP patients. Verbal memory scores correlated to regional cortical thinning in the insula whereas visual memory scores correlated to parietal thinning. Conclusions: This multicenter study showed mild global cortical thinning in RRMS. The extent of thinning is less pronounced than previously reported. Only subtle regional differences between CI and CP patients were observed, some of which related to specific cognitive domains.

Original languageEnglish (US)
Pages (from-to)901-909
Number of pages9
JournalMultiple Sclerosis
Volume22
Issue number7
DOIs
StatePublished - Jun 1 2016

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Multicenter Studies
Multiple Sclerosis
Relapsing-Remitting Multiple Sclerosis
Linear Models
Cognitive Dysfunction
Brain

Keywords

  • cognitive impairment
  • cortical atrophy
  • MRI
  • Multiple sclerosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Regional cortical thinning in multiple sclerosis and its relation with cognitive impairment : A multicenter study. / Tillema, Jan-Mendelt; Hulst, H. E.; Rocca, M. A.; Vrenken, H.; Steenwijk, M. D.; Damjanovic, D.; Enzinger, C.; Ropele, S.; Tedeschi, G.; Gallo, A.; Ciccarelli, O.; Rovira, A.; Montalban, X.; De Stefano, N.; Stromillo, M. L.; Filippi, M.; Barkhof, F.

In: Multiple Sclerosis, Vol. 22, No. 7, 01.06.2016, p. 901-909.

Research output: Contribution to journalArticle

Tillema, J-M, Hulst, HE, Rocca, MA, Vrenken, H, Steenwijk, MD, Damjanovic, D, Enzinger, C, Ropele, S, Tedeschi, G, Gallo, A, Ciccarelli, O, Rovira, A, Montalban, X, De Stefano, N, Stromillo, ML, Filippi, M & Barkhof, F 2016, 'Regional cortical thinning in multiple sclerosis and its relation with cognitive impairment: A multicenter study', Multiple Sclerosis, vol. 22, no. 7, pp. 901-909. https://doi.org/10.1177/1352458515607650
Tillema, Jan-Mendelt ; Hulst, H. E. ; Rocca, M. A. ; Vrenken, H. ; Steenwijk, M. D. ; Damjanovic, D. ; Enzinger, C. ; Ropele, S. ; Tedeschi, G. ; Gallo, A. ; Ciccarelli, O. ; Rovira, A. ; Montalban, X. ; De Stefano, N. ; Stromillo, M. L. ; Filippi, M. ; Barkhof, F. / Regional cortical thinning in multiple sclerosis and its relation with cognitive impairment : A multicenter study. In: Multiple Sclerosis. 2016 ; Vol. 22, No. 7. pp. 901-909.
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AU - Tillema, Jan-Mendelt

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AU - Rocca, M. A.

AU - Vrenken, H.

AU - Steenwijk, M. D.

AU - Damjanovic, D.

AU - Enzinger, C.

AU - Ropele, S.

AU - Tedeschi, G.

AU - Gallo, A.

AU - Ciccarelli, O.

AU - Rovira, A.

AU - Montalban, X.

AU - De Stefano, N.

AU - Stromillo, M. L.

AU - Filippi, M.

AU - Barkhof, F.

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